低强度抗凝对老年稳定性冠心病并发非瓣膜性心房颤动患者疗效及安全性的影响  

Influence of low anticoagulation strength on clinical effects and safety of elderly patients with stable coronary artery disease complicated with nonvalvular atrial fibrillation

作　　者：刘全未[1] 邵阳[2] LIU Quan-wei;SHAO Yang(Department of Cardiology,The Second People′s Hospital of Neijiang City,Neijiang,Sichuan 641100,China;Department of Laboratory, The Second People′s Hospital of Neijiang City,Neijiang,Sichuan 641100, China)

机构地区：[1]内江市第二人民医院心血管内科,四川内江641100 [2]内江市第二人民医院检验科,四川内江641100

出　　处：《岭南心血管病杂志》2019年第3期299-302,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨低强度和中强度华法林抗凝对老年稳定性冠状动脉粥样硬化性心脏病(coronary artery disease,CAD)并发非瓣膜性心房颤动患者疗效及安全性终点事件的影响。方法选取内江市第二人民医院2014年7月至2017年2月收治的老年稳定性CAD并发非瓣膜性心房颤动患者共120例,根据华法林抗凝强度不同分为A组(60例)和B组(60例),分别采用低强度和中强度华法林抗凝治疗,比较两组患者主要终点事件发生率,次要终点事件发生率及安全性终点事件发生率。结果两组患者缺血性脑卒中和体循环栓塞发生率比较,差异无统计学意义(P>0.05)。两组患者非致命性心肌梗死和全因死亡发生率比较,差异无统计学意义(P>0.05);B组患者总出血发生率显著高于A组,差异有统计学意义(16.67%vs.3.33%,P<0.05)。结论低强度和中强度华法林抗凝治疗老年稳定性CAD并发非瓣膜性心房颤动患者总体疗效接近,但低强度华法林抗凝安全性更佳。Objectives To investigate the low degree and middle degree warfarin anticoagulation strength on clinical effects and safety endpoints of elderly patients with stable coronary artery disease(CAD)complicated with nonvalvular atrial fibrillation. Methods Totally 120 elderly patients with stable CAD complicated with nonvalvular atrial fibrillation were chosen in the period from July 2014 to February 2017 in The Second Peoples Hospital of Neijiang City and divided into 2 groups according to warfarin anticoagulation strength,including A group(60 patients)with low degree warfarin anticoagulation strength and observation B group (60 patients) with middle degree warfarin anticoagulation strength. Incidences of primary end point event,secondary endpoint event and safety endpoint event of both groups were compared. Results There were no significant differences in incidences of ischemic stroke and systemic embolism between the two groups(P>0.05). There were no significant differences in incidences of nonfatal myocardial infarction and all-cause death between the two groups(P>0.05). Incidence of total bleeding event in B group was significant higher than that in A group(16.67% vs. 3.33%,P<0.05). Conclusions Low degree and middle degree warfarin anticoagulation strength in treatment of elderly patients with stable CAD complicated with nonvalvular atrial fibrillation possess the same clinical effects;but low degree warfarin anticoagulation strength application has a better safety.

关 键 词：冠状动脉疾病 心房颤动 华法林 抗凝强度 

分 类 号：R541.4[医药卫生—心血管疾病] R541.7[医药卫生—内科学]