p73基因与精子的发生及成熟  

p73 gene and spermatogenesis and maturation

作　　者：王桐生[1] 吴德玲[2] 李莉[1] 那莎[3] WANG Tongsheng;WU Delin;LI Li;NA Sha(Department of Pharmacology,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China;Scientific Research Office,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China;Department of Biochemistry,Anhui University of Chinese Medicine,Hefei 230012,Anhui,China)

机构地区：[1]安徽中医药大学药理学教研室,安徽合肥230012 [2]安徽中医药大学科研处,安徽合肥230012 [3]安徽中医药大学生物化学教研室,安徽合肥230012

出　　处：《中国临床药理学与治疗学》2019年第6期712-715,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金面上项目(81473674)

摘　　要：p73作为p53家族的一员,其结构与功能与p53具有极其相似之处,在抑制肿瘤的发生发展方面已广为熟知。近来研究发现,p73基因调控精子的发生及成熟,影响雄性生殖能力,因此其在男性生殖领域的独特作用备受关注。p73基因有两种具有不同功能的亚型(TAp73和ΔNp73),不仅影响生殖细胞与Sertoli细胞间的粘附与迁移,而且影响精子的凋亡。本文将对p73基因的结构及在生殖细胞发生、成熟中的生物学功能进行简要阐述,以期对男性生殖系统疾病的诊断与治疗提供新思路。p73 is a member of the p53 family. Its structure and function are very similar to p53. It has been well known in inhibiting the occurrence and development of tumors. Recent studies have found that p73 gene regulates spermatogenesis and maturation and affects male reproductive ability. Therefore, its unique role in male reproduction has attracted much attention. The p73 gene has two different functional subtypes (TAp73 and delta Np73), which not only affect the adhesion and migration between the germ cells and the Sertoli cells, but also affect the apoptosis of the sperm. In this paper, the structure of the p73 gene and its biological function in the maturation of germ cells will be briefly described in order to provide new ideas for the diagnosis and treatment of male reproductive system diseases.

关 键 词：P73基因 男性生殖系统 精子凋亡 

分 类 号：R699[医药卫生—泌尿科学]