慢性肾功能衰竭患者血液透析前后听功能改变  

Changes in auditory function before and after hemodialysis in patients with chronic renal failure

作　　者：王振 付涛[2] 刘丽庭[3] WANG Zhen;FU Tao;LIU Li-ting(Department of Medicine,Qingdao University,Qingdao,Shandong 266071,China)

机构地区：[1]青岛大学医学部,山东青岛266071 [2]青岛大学附属医院耳鼻咽喉头颈外科 [3]潍坊市人民医院耳鼻咽喉科

出　　处：《青岛医药卫生》2019年第3期193-196,共4页Qingdao Medical Journal

摘　　要：目的分析慢性肾功能衰竭患者血液透析前后听功能情况。方法随机选取2018年6月至2018年12月就诊于潍坊市人民医院血液净化中心的慢性肾功能衰竭患者25例(50耳)作为试验对象,在血液透析开始前1h和结束后1h分别进行纯音测听检查和畸变产物耳声发射(Distortion product otoacoustic emission,DPOAE)检查,对两组数据进行统计学分析。结果(1)血液透析前后纯音测听在0.25、0.5、1.0 kHz处平均阈值分别为(26.67±9.55)dB和(16.39±6.14)dB、(24.72±7.17)dB和(17.22±5.208)dB、(23.61±7.03)dB和(21.39±5.64)dB,差异有统计学意义(P<0.05),其余频率差异无统计学意义(P>0.05)。(2)血液透析前后DPOAE在0.7、1.0 kHz处的平均幅值分别为(-1.39±7.15)dB SPL和(3.28±7.72)dB SPL、(-4.39±12.19)dB SPL和(1.33±8.17)dB SPL,差异有统计学意义(P<0.05),其余频率幅值变化不明显(P>0.05)。(3)血液透析后DPOAE在0.7 kHz处通过率有明显提升(P<0.05)。结论透析治疗在短期内会对患者低频听功能产生正面影响,而对高频听功能的影响并不显著。Objective To analyze the auditory function of patients with chronic renal failure before and after hemodialysis. Methods Twenty-five patients(50 ears) with renal failure who were admitted to the blood purification center of Weifang People’s Hospital from June 2018 to December 2018 were randomly selected as test subjects. Pure tone audiometry and distortion product otoacoustic emission(Distortion product otoacoustic emission,DPOAE) were performed 1 hour before and 1 hour after hemodialysis. Statistical analysis of the two sets of data was performed. Results The mean thresholds of pure tone audiometry at 0.25, 0.5, and 1.0 kHz before and after hemodialysis were(26.67±9.55) dB and(16.39±6.14) dB,(24.72±7.17) dB and(17.22±5.208) dB,(23.61±7.03) dB and(21.39±5.64) dB, respectively. The difference between the comparison groups was statistically significant(P<0.05), and the difference between the other frequency comparison groups was not obvious(P>0.05). The mean amplitudes of DPOAE at 0.7 and 1.0 k Hz before and after hemodialysis were(-1.39±7.15) dB SPL and(3.28±7.72) dB SPL,(-4.39±12.19) dB SPL and(1.33±8.17), respectively. The difference between the comparison groups was statistically significant(P<0.05), and the amplitude of the remaining frequencies was not significant(P>0.05). The pass rate of DPOAE at 0.7 kHz after hemodialysis was significantly improved(P<0.05). Conclusion Dialysis treatment will have a positive impact on the low-frequency listening function of patients in the short term, but the effect on high-frequency listening function is not significant.

关 键 词：听功能 血液透析 肾功能衰竭 

分 类 号：R764.431[医药卫生—耳鼻咽喉科]