纳米Fe3O4双歧杆菌脂磷壁酸对轮状病毒肠炎的疗效及对血清IL-6、PCT、CRP水平的影响  

Effects of nano-Fe3O4 bifidobacterium lipoteichoic acid on rotavirus enteritis and serum IL-6,PCT and CRP levels

作　　者：陈婉婵 刘见欢 梁逸仙 崔业佳 黄金时 蒲荣 CHEN Wanchan;LIU Jianhuan;LIANG Yixian;CUI Yejia;HUANG Jinshi;PU Rong(Department of Clinical Laboratory,Dongguan Third People′sHospital,Dongguan,Guangdong 523326,China)

机构地区：[1]东莞市第三人民医院检验科

出　　处：《检验医学与临床》2019年第12期1653-1655,1658,共4页Laboratory Medicine and Clinic

基　　金：东莞市科技计划医疗卫生类科研一般项目(2018507150241501);东莞市社会科技发展(重点)项目(2016108101021,2018507150241638)

摘　　要：目的 探讨纳米Fe 3O 4双歧杆菌脂磷壁酸对轮状病毒肠炎的疗效及对血清白细胞介素(IL)-6、降钙素原(PCT)、C反应蛋白(CRP)水平的影响。方法 由动物实验室采购40只健康雄性SD大鼠,将所有大鼠随机分为对照组与研究组,每组20只,并制成轮状病毒肠炎大鼠模型。对照组大鼠使用传统治疗方式,研究组大鼠在对照组基础上加用纳米Fe 3O 4双歧杆菌脂磷壁酸。比较两组大鼠治疗后的临床效果、血清IL-6、PCT、CRP水平变化情况。结果 研究组大鼠治疗有效率高于对照组( P <0.05);治疗后,两组大鼠的血清IL-6、PCT、CRP水平较治疗前均有所下降( P <0.05),且研究组大鼠的3种指标水平低于对照组( P <0.05);研究组大鼠止泻时间、退热时间均短于对照组( P <0.05);研究组大鼠治疗5 d后及10 d后的轮状病毒转阴率均高于对照组( P <0.05)。结论 纳米Fe 3O 4双歧杆菌脂磷壁酸治疗轮状病毒肠炎疗效显著,炎性反应较轻,有降低血清IL-6、PCT、CRP水平的效果,转阴率较高,但应用于临床中是否有效,仍需大量研究提供依据。Objective To investigate the effect of nano-Fe 3O 4 bifidobacterium lipoteichoic acid on rotavirus enteritis and the levels of serum interleukin (IL)-6,procalcitonin (PCT) and C-reactive protein (CRP). Methods Forty healthy male Sprague-Dawley rats were purchased from animal laboratories.All rats were randomly divided into control group and study group,with 20 rats in each group,and made into a rat model of rotavirus enteritis.The rats in the control group were treated with traditional treatment.The rats in the study group were added with nano-Fe 3O 4 bifidobacterium lipoteichoic acid on the basis of the control group.The clinical effects and serum IL-6,PCT and CRP levels of the two groups were compared after treatment. Results The clinical efficacy of the study group was higher than that of the control group ( P < 0.05 ).After treatment,the serum levels of IL-6,PCT and CRP in the two groups were lower than those before treatment ( P < 0.05 ),and the indicators of study group were significantly lower than that in the control group ( P < 0.05 ).The antidiarrheal time and abatement of fever of the study group were significantly lower than that of the control group ( P < 0.05).The rates of negative conversion 5 days and 10 days after treatment in the study group were significantly higher than that of the control group ( P <0.05). Conclusion Nano-Fe 3O 4 bifidobacterium lipoteichoic acid has a good effect in alleviating rotavirus enteritis,which has better effect and less inflammation.And serum IL-6,PCT and CRP levels are lower,but they are still needed to be further researched.

关 键 词：纳米FE 3O 4双歧杆菌脂磷壁酸 轮状病毒肠炎 治疗效果 

分 类 号：R446.1[医药卫生—诊断学]