慢性血小板减少症免疫机制的研究进展  

Research progress on immune mechanism of chronic immune thrombocytopenia

作　　者：黄倩[1] 刘燕[1] 蔡力肖[1] 孙语眉 Huang Qian;Liu Yan;Cai Lixiao;Sun Yumei(Department of Hematology and Oncology Baoding Children Hospital,Baoding 071000,China)

机构地区：[1]保定市儿童医院血液肿瘤科,河北保定071000

出　　处：《国际免疫学杂志》2019年第3期333-336,F0003,共5页International Journal of Immunology

摘　　要：免疫性血小板减少症(immune thrombocytopenia,ITP)是儿童常见的出血性疾病,部分患儿病程迁延,成为慢性血小板减少症(chronic immune thrombocytopenia,CITP)。CITP困扰着许多患者及其家庭,其免疫机制较为复杂,与急性ITP的免疫机制不尽相同,其中涉及固有免疫、适应性免疫等方面。现就血小板的生成减少、破坏增加及功能受限等的免疫机制进行探讨,为临床工作提供理论依据。Immune thrombocytopenia(ITP)is a common hemorrhagic disease in children.Some children,who have a prolonged course of disease,may develop to chronic thrombocytopenia(CITP).The immune mechanism associated with CITP is complicated,which is different from that of acute ITP.The mechanism of CITP involves innate immune,adaptive immunity,etc.This review discussed the immune mechanism of reduced platelet production,increased destruction of platelet,and declined function of platelets.

关 键 词：慢性血小板减少症 血小板抗体 固有免疫 适应性免疫 

分 类 号：R725.5[医药卫生—儿科]