糖尿病肾病损伤标志物的研究进展  

Reserch progress of damage markers of diabetic nephropathy

作　　者：周蓓蓓 杨帆[2] ZHOU Beibei;YANG Fan(College of Graduate, Guilin Medical University, Guilin 541004,China)

机构地区：[1]桂林医学院研究生学院,广西桂林541004 [2]桂林医学院附属医院内分泌科,广西桂林541001

出　　处：《华夏医学》2019年第1期162-165,共4页Acta Medicinae Sinica

基　　金：国家自然科学基金资助项目(81460160);广西自然科学基金资助项目(2014GXNSFBA118191)

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病患者最常见的并发症之一。早期肾脏损害是以肾小管的损伤为主,然后常规的肌酐、尿素氮等检测指标并未明显升高,因此,早期发现T2DM患者损伤标志物升高对于早期诊断DN具有重要意义。笔者就血清视黄醇结合蛋白(RBP)、转铁蛋白(TRSF)、N-乙酰-β-氨基葡萄糖糖苷酶(NAG)、α1-微球蛋白(α1-MG)、胱抑素C(CysC)、脂联素(ADPN)等肾脏损伤标志物早期对糖尿病肾病的发生发展作用进行综述。Diabetic nephropathy(DN)is one of the most common complications of diabetic patients. The arly renal damage is mainly caused by damage of renal tubules, and then the routine detection indexes such as creatinine and urea nitrogen have not been significantly increased. Therefore, the early detection of increased damage markers in T2 DM patients is of great significance for the early diagnosis of DN. In this paper, we review the roles of such early kidney damage markers as RBP, TRSF, NAG,α1-MG, CysC and ADPN in the occurrence and development of DN.

关 键 词：糖尿病 糖尿病肾病 损伤标志物 

分 类 号：R587.1[医药卫生—内分泌]