莪术油注射液联合奥司他韦治疗小儿病毒性肺炎的临床研究  

Clinical study of Zedoary Turmeric Oil Injection combined with oseltamivir in treatment of children with viral pneumonia

作　　者：王平乐 朱敏 张伟[1] WANG Ping-le;ZHU Min;ZHANG Wei(Huaibei Miners General Hospital Group,Huaibei 235000,China)

机构地区：[1]淮北矿工总医院集团儿科,安徽淮北235000

出　　处：《现代药物与临床》2019年第5期1406-1409,共4页Drugs & Clinic

摘　　要：目的探讨莪术油注射液联合奥司他韦治疗小儿病毒性肺炎的临床疗效。方法选取2016年10月—2018年10月淮北矿工总医院收治的病毒性肺炎患儿101例,随机分为对照组(50例)和治疗组(51例)。对照组口服磷酸奥司他韦颗粒,体质量<15 kg者30 mg/次,体质量15～23 kg者45 mg/次,体质量23～40 kg者60 mg/次,体质量>40 kg者75 mg/次,2次/d。治疗组患儿在对照组治疗基础上静脉滴注莪术油注射液,10 mL/次加入生理盐水250 mL稀释,1次/d。两组患儿均治疗7 d。观察两组的临床疗效,比较两组患儿喘憋消失时间、体温恢复正常时间及X线恢复正常时间。比较两组治疗前后血清白细胞介素-8(IL-8)、C反应蛋白(CRP)、肌酸激酶(CK)和心肌肌钙蛋白(CTnT)的变化情况。结果治疗后,对照组和治疗组的总有效率分别是78.00%、94.12%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患儿喘憋消失时间、体温恢复正常时间及X线恢复正常时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清IL-8、CRP、CK、CTnT水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组这些血清学指标显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论莪术油注射液联合奥司他韦治疗小儿病毒性肺炎具有较好的临床疗效,能显著改善患者临床症状,降低血清因子水平,具有一定的临床推广应用价值。Objective To investigate the clinical efficacy of Zedoary Turmeric Oil Injection combined with oseltamivir in treatment of children with viral pneumonia.Methods Children (101 cases) with viral pneumonia in Huaibei Miners General Hospital Group from October 2016to October 2018 were randomly divided into control (50 cases) and treatment (51 cases) groups.Patients in the control group were po administered with Oseltamivir Phosphate Granules,body mass < 15 kg,30 mg/time;body mass 15-23 kg,45 mg/time;body mass 23-40 kg,60 mg/time;body mass > 40 kg,75 mg/time,twice daily.Patients in the treatment group were iv administered with Zedoary Turmeric Oil Injection on the basis of the control group,10 mL/time added into normal saline 250 mL for dilution,once daily.Patients in two groups were treated for 7 d.After treatment,the clinical efficacy was evaluated,and wheezing recovery time,body temperature recovery time and X-ray recovery time in two groups were compared.The changes of IL-8,CRP,CK,and CTnT before and after treatment in two groups were compared.Results After treatment,the clinical efficacy in the control and treatment groups were 78.00% and 94.12%,respectively,and there were differences between two groups (P < 0.05).After treatment,wheezing recovery time,body temperature recovery time and X-ray recovery time in the treatment group were shorter than those in the control group,and there were differences between two groups (P < 0.05).After treatment,IL-8,CRP,CK,and CTnT in two groups were significantly decreased,and there were differences in the same group (P < 0.05).After treatment,the levels of those serological indicators in the treatment group were lower than those in the control group,and there were differences between two groups (P < 0.05).Conclusion Zedoary Turmeric Oil Injection combined with oseltamivir has significant effect in treatment of children with viral pneumonia,and can significantly improve the clinical symptoms,and also can reduce serum factor levels,which has a certain clinical application value.

关 键 词：莪术油注射液 奥司他韦颗粒 小儿病毒性肺炎 白细胞介素-8 C-反应蛋白 肌酸激酶 心肌肌钙蛋白 

分 类 号：R985[医药卫生—药品]