丹参酮ⅡA磺酸钠精制工艺研究  

Study on Refining Process of Sodium Tanshinone IIA Sulfonate

作　　者：杨妍华[1] YANG Yan-hua(Department of Pharmacy,Changzhou Seventh People's Hospital,Changzhou Jiangsu 213000,China)

机构地区：[1]常州市第七人民医院药事科

出　　处：《国际感染病学（电子版）》2018年第3期191-192,共2页Infection International(Electronic Edition)

基　　金：常州科技局应用基础研究(编号:CJ20189001)

摘　　要：目的:探讨丹参酮ⅡA磺酸钠原料的精制工艺。方法:采用高效液相色谱法研究了不同精制条件对丹参酮ⅡA磺酸钠原料含量和得率的影响。结果:采用乙醇的水溶液和硅藻土进行回流,重结晶的方法是丹参酮ⅡA磺酸钠原料的最佳精制工艺条件。结论:该研究可为丹参酮ⅡA磺酸钠原料的工业制备提供指导性建议。Objective:To study the refining process of sodium tanshinoneⅡA sulfonate.Methods:The effects of different refining conditions on the content and yield of sodium tanshinoneⅡA sulfonate were studied by high performance liquid chromatography.Result:The best refining technology of tanshinoneⅡA sodium sulfonate was reflux of ethanol solution and diatomite and recrystallization.Conclusion:This study can provide guidance for the industrial preparation of sodium tanshinoneⅡA sulfonate.

关 键 词：参酮ⅡA 磺酸钠 精制工艺 高效液相色谱 

分 类 号：R283.6[医药卫生—中药学]