补虚通痹方治疗特发性肺间质纤维化疗效观察  

Observation on Clinical Effects of BuXu TongBi Prescriptions in the Treatment for Idiopathic Pulmonary Fibrosis

作　　者：樊茂蓉[1,2] 徐凤芹[1] 王冰[1] 韩克华[3] 樊长征[1] 张琼[1] 苗青[1] FAN Maorong;XU Fengqin;WANG Bing;HAN Kehua;FAN Changzheng;ZHANG Qiong;MIAO Qing(Department of Respiratory Medicine,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Beijing University of Chinese Medicine;Weifang City TCM Hospital)

机构地区：[1]中国中医科学院西苑医院呼吸科,北京100091 [2]北京中医药大学 [3]潍坊市中医院

出　　处：《西部中医药》2019年第5期77-80,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(编号81774297);北京市自然科学基金(编号7126168);北京市科学技术委员会课题(编号Z131107002213053)

摘　　要：目的:观察补虚通痹方治疗特发性肺间质纤维化(idiopathic pulmonary fibrosis,IPF)的疗效及安全性。方法:将IPF患者60例随机分为对照组和观察组各30例,对照组采用大剂量N-乙酰半胱氨酸及按需氧疗治疗,观察组采用补虚通痹方加按需氧疗治疗,疗程3个月,随访3个月。比较2组患者治疗前后6分钟步行距离、生活质量、中医证候积分、呼吸困难及咳嗽单项症状积分、肺功能变化情况。结果:观察组在延长6分钟步行距离、改善患者呼吸困难及咳嗽症状方面优于对照组,并且观察组能够稳定患者肺功能,未发现严重不良反应。结论:补虚通痹方能提高IPF患者活动耐力、改善患者呼吸困难及咳嗽症状并稳定患者肺功能,且安全性好。Objective: To observe clinical effects and the safety of BuXu TongBi prescription in the treatment for idiopathic pulmonary fibrosis (IPF). Methods: Sixty patients were randomized into the control group and the observation group, 30 cases each group, the control group adopted large dose of N acetylcysteine (NAC) and on- demand oxygen therapy, the observation group used BuXu TongBi prescription and on-demand oxygen therapy, the course was three months, they were followed for three months. To compare six-minutes walking distance, life quality, TCM syndrome scores, the scores of difficult breathing and single item of cough and the changes of pulmonary function between both groups. Results: Th observation group was superior to the control group in prolonging six minutes walking distance, improving dyspnea and cough, and the observation group could stabilize pulmonary function, and no severe adverse reaction happened. Conclusion: BuXu TongBi prescription could raise exercise endurance of IPF patients, improve dyspnea and cough, stabilize pulmonary function with good safety.

关 键 词：特发性肺间质纤维化 肺功能 补虚通痹方 

分 类 号：R563[医药卫生—呼吸系统]