道地药材“邓菊”之本草考证及南阳菊花的品质评价  

Herbal Textual Research on Genuine Medicinal Materials "Deng Ju" and Quality Evaluation of Nan Yang Chrysanthemi Flos

作　　者：郝鹏飞 张思源[1] 杜智慧 卞华 黄显章 HAO Peng-fei;ZHANG Si-yuan;DU Zhi-hui;BIAN Hua;HUANG Xian-zhang(Nanyang Institute of Technology,Zhang Zhongjing College of Chinese Medicine, Nanyang 473000,China;Nanyang Institute of Technology, Henan Key Laboratory of Zhang Zhongjing Formulae and, Herbs for Immunoregulation,Nanyang 473000,China)

机构地区：[1]南阳理工学院张仲景国医国药学院,河南南阳473000 [2]南阳理工学院河南省张仲景方药与免疫调节重点实验室,河南南阳473000

出　　处：《中国实验方剂学杂志》2019年第12期187-194,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省张仲景基金会资助项目

摘　　要：目的:考证南阳菊花的本草源流,溯源其盛衰史,再通过现代分析方法对现今南阳菊花进行品质评价,阐明南阳地产菊花之优势。方法:通过考证《中华医典》及相关古文献对南阳菊花的记载,阐明南阳古代菊花的源流、应用,自古文献中揭示南阳菊花与其他菊花品种的亲缘关系;再通过高效液相色谱一测多评法,对14批菊花中的包含2015年版《中国药典》指标在内的8种化学成分进行含量测定,依据结果进行综合加权评分分析;另建立14批菊花的高效液相色谱指纹图谱,并对其进行相似度、聚类分析,以期综合评价现今南阳菊花质量,并从化学成分层面阐明南阳菊花与其他产地菊花的亲缘关系。结果:本草考证显示南阳菊花自汉朝以后流传各地,后世众多药用菊花均受南阳菊花之影响;指纹图谱的相似度、聚类分析也进一步证实南阳菊花与多种菊花在化学层面上存在亲缘关系; 2015年版《中国药典》指标检测及综合评分分析结果则显示南阳菊花品质较好,非常适宜药用。结论:南阳从古至今皆为菊花优质产区,南阳菊花非常适宜药用,值得大力推广种植。Objective: To study the origin of Nanyang Chrysanthemi Flos materia medica and its historical origin,in order to evaluate the quality of Nanyang Chrysanthemi Flos by HPLC method,and define the advantages of Nanyang Chrysanthemi Flos with the origin of Nanyang. Method: Records of Nanyang Chrysanthemi Flos in the " Chinese Medical Code" and related ancient documents were studied to explain the origin and application. The genetic relationship between Nanyang Chrysanthemi Flos and other pieces was revealed in ancient literatures. Then8 chemical constituents in 14 batches of Chrysanthemi Flos were determined by HPLC multi-components quantitation,and the comprehensive weighted score analysis was performed based on the results. The HPLC fingerprints were established, and the similarity analysis and clustering analysis were made to comprehensive evaluation the quality of Nanyang Chrysanthemi Flos and define the genetic relationship between Nanyang and other pieces at the chemical composition level. Result: The results of the herbal textual research show that Nanyang Chrysanthemi Flos spread from place to place since the Han dynasty,and impact many medicinal chrysanthemums of later generations. HPLC fingerprints similarity and cluster analysis also indicated the genetic relationship between Nanyang Chrysanthemi Flos and other species at the chemical level. The comprehensive score analysis results show that Nanyang Chrysanthemi Flos is of good quality and very suitable for medicinal purposes. Conclusion: Nanyang has been a quality production area of Chrysanthemi Flos since ancient times to present. Nanyang Chrysanthemi Flos is very suitable for medicinal purposes and worthy of promotion.

关 键 词：南阳菊花 本草考证 指纹图谱 品质评价 

分 类 号：R284.1[医药卫生—中药学] R2-031[医药卫生—中医学]