舒芬太尼联合右美托咪定延长宫颈癌术后镇痛时效的临床研究  

Clinical study of sufentanil combined with dexmedetomidine for prolonging the analgesic effect after cervical cancer surgery

作　　者：郭兆麟[1] 毛丽君[1] 陈金华 谢海辉[1] 卢少丽[1] 陈慧娴[1] GUO Zhao-lin;MAO Li-jun;CHEN Jin-hua;XIE Hai-hui;LU Shao-li;CHEN Hui-xian(Department of Anesthesiology,Dongguan People’s Hospital,Guangdong Dongguan 523059,China)

机构地区：[1]广东省东莞市人民医院麻醉科

出　　处：《中国医刊》2019年第7期748-751,共4页Chinese Journal of Medicine

摘　　要：目的 探讨舒芬太尼联合右美托咪定延长宫颈癌术后镇痛时效的临床效果。方法 选取2017年6月至2018年5月在广东省东莞市人民医院行宫颈癌手术的96例患者,采用双色球法随机分为对照组和观察组,每组48例。其中对照组术后给予舒芬太尼镇痛,观察组术后给予舒芬太尼联合右美托咪定镇痛,比较分析两组患者术后不同时间点的生命体征、疼痛程度、Ramsay镇静评分及麻醉相关不良反应发生情况。结果 两组患者术后不同时间点的心率、平均动脉压和血氧饱和度比较差异无显著性(P>0.05)。对照组术后不同时间点的呼吸频率及疼痛评分明显高于观察组,Ramsay镇静评分明显低于观察组,差异均有显著性(P<0.05)。对照组术后麻醉相关不良反应发生率为22.92%,明显高于观察组的4.17%,差异有显著性(P<0.05)。结论 宫颈癌术后联合应用舒芬太尼和右美托咪定可明显延长镇痛时间,提高镇痛和镇静效果,且安全性较高。Objective To study the clinical effect of sufentanil combined with dexmedetomidine in prolonging the analgesic efficacy of cervical cancer patients after operation. Method Ninety-six patients who underwent cervical cancer surgery from June 2017 to May 2018 were randomly divided into control group and combination group with 48 cases in each group. The control group was given sufentanil for postoperative analgesia, and the combined group was given sufentanil and dexmedetomidine for postoperative analgesia. The vital signs, postoperative pain, Ramsay sedation score and adverse reactions of the two groups were compared and analyzed. Result There was no significant difference in HR, MAP and SpO2 between the two groups at different time after operation (P> 0.05). The Rs of the control group at different time after operation were significantly higher than those of the combined group, the difference was statistically significant (P<0.05). The VAS scores of the patients in the control group at different time after operation were significantly higher than those in the combined group, and the difference was statistically significant (P<0.05). The Ramsay sedation score of the control group at different time after operation was significantly lower than that of the combined group (P<0.05). The anesthesia related incidence of adverse reactions in the control group and the combined group were 22.92% and 4.17%, respectively, with statistical significance (P<0.05). Conclusion Sufentanil combined with dexmedetomidine for analgesia after cervical cancer surgery can significantly prolong the postoperative analgesia time, improve the analgesic effect and sedative effect, and has high safety.

关 键 词：舒芬太尼 右美托咪定 宫颈癌 术后镇痛 

分 类 号：R614.21[医药卫生—麻醉学]