miRNA与糖尿病性微血管损伤与修复的研究进展  

Research progress of miRNA in diabetic microvascular injury and repair

作　　者：王文一[1] 罗迪[1] 张依然[1] 王珏[1] Wang Wenyi;Luo Di;Zhang Yiran;Wang Yu(International Center of Diagnosis and Treatment,Tianjian First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院国际诊疗中心,300192

出　　处：《国际医药卫生导报》2019年第12期1921-1923,共3页International Medicine and Health Guidance News

基　　金：天津市卫生局面上项目(2014KY13).

摘　　要：糖尿病是一种常见的代谢性疾病,血糖浓度长期偏高可导致多器官、系统的微血管损伤并引起一系列并发症,其中糖尿病心肌病症状最为严重。研究表明,miRNA参与糖尿病性心脏病变的发生发展,并能引起血管内皮细胞的生成及功能障碍等。本文miRNA及在糖尿病心肌病的微血管病变及新生机制中的作用作一综述。Long-term diabetes can lead to multiple organ,systemic microangiopathy and a series of complications;among which,diabetic cardiomyopathy is the most serious.Research has shown that miRNAs involve in the development of diabetic heart disease and can cause the formation and dysfunction of vascular endothelial cells.This article reviews the role of miRNA in diabetic-cardiomyopathy-related microangiopathy and its mechanism.

关 键 词：MIRNA 糖尿病心肌病 微血管 

分 类 号：R587.2[医药卫生—内分泌]