依达拉奉联合亚低温治疗重型颅脑损伤的临床效果  

Clinical effect of Edaravone combined with mild hypothermia in the treatment of severe craniocerebral injury

作　　者：钟贤良[1] 杜波[1] 钟源波 徐建忠 单爱军[1] ZHONG Xian-liang;DU Bo;ZHONG Yuan-bo;XU Jian-zhong;SHAN Ai-jun(Department of Emergency, the Second Clinical Medical College of Ji'nan University, Shenzhen Peopler s Hospital,Guangdong Province, Shenzhen 518020, China)

机构地区：[1]暨南大学第二临床医学院深圳市人民医院急诊科

出　　处：《中国当代医药》2019年第15期58-61,共4页China Modern Medicine

基　　金：广东省深圳市卫计委重点学科建设能力提升项目(201506009)

摘　　要：目的探讨依达拉奉联合亚低温治疗重型颅脑损伤的临床价值.方法选取2015年1月~2016年12月我院急诊病房及监护室收治的89例重型颅脑损伤患者作为研究对象,按照随机数字表法将其分为对照组(n=44)与观察组(n=45).对照组患者采用依达拉奉治疗,观察组患者采用依达拉奉联合亚低温治疗.比较两组患者治疗前后的神经功能缺损(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、大脑中动脉血流速度(Vm)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及氧化应激指标[超氧化物歧化酶1(SOD-1)、丙二醛(MDA)].结果两组患者治疗前的NIHSS评分、GCS评分、Vm比较,差异无统计学意义(P>0.05);两组患者治疗后的NIHSS评分均明显低于治疗前,GCS评分、Vm均明显高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的NIHSS评分明显低于对照组,GCS评分、Vm均明显高于对照组,差异有统计学意义(P<0.05).两组患者治疗前的TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);两组患者治疗后的TNF-α、IL-6水平均明显低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05).两组患者治疗前的SOD-1、MDA水平比较,差异无统计学意义(P>0.05);两组患者治疗后的SOD-1水平均高于治疗前,MDA水平均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的SOD-1水平高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05).结论采用依达拉奉与亚低温联合方式治疗重型颅脑损伤患者效果显著,应用前景良好.Objective To investigate the clinical value of Edaravone combined with mild hypothermia in the treatment of severe craniocerebral injury. Methods A total of 89 patients with severe craniocerebral injury admitted to the emergency ward and intensive care unit of our hospital from January 2015 to December 2016 were selected as the study subjects. They were divided into the control group (n=44) and the observation group (n=45) according to the random number table method. Patients in the control group were treated with Edaravone, and patients in the observation group were treated with Edaravone combined with mild hypothermia. The neurological deficit (NIHSS) scores, Glasgow coma scale (GCS) scores, middle cerebral artery blood flow velocity (Vm), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) and oxidative stress indicators [superoxide dismutase 1 (SOD-1), malondialdehyde (MDA)] were compared between the two groups before and after treatment. Results There were no significant difference in NIHSS score, GCS score and Vm between the two groups before treatment (P>0.05). The NIHSS scores of the two groups after treatment were significantly lower than those before treatment, the GCS scores and Vm were significantly higher than those before treatment, and the differences were statistically significant (P<0.05). The NIHSS score in the observation group after treatment was significantly lower than those in the control group, the GCS score and Vm were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). There were no significant difference in the levels of TNF-α and IL-6 between the two groups before treatment (P>0.05). The levels of TNF-α and IL- 6 of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (Pv0.05). The levels of TNF-a and IL-6 in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05). T

关 键 词：依达拉奉 亚低温 重型颅脑损伤 神经功能缺损 昏迷 氧化应激 

分 类 号：R651.15[医药卫生—外科学]