肠内营养支持对老年重症肺炎营养状况及T淋巴细胞亚群的影响  

Effect of Enteral Nutrition Support on Nutritional Level and T Lymphocyte Subsets in Elderly Patients with Severe Pneumonia

作　　者：邢华燕[1] 牛琳[1] 宁静 侯园园[1] 胡丹华 XING Hua-yan;NIU Lin;NING Jing;HOU Yuan-yuan;HU Dan-hua(Zhengzhou Railway Vocational and Technical College,Zhengzhou 450000,China;The Ninth People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州铁路职业技术学院,河南郑州450000 [2]郑州市第九人民医院,河南郑州450000

出　　处：《河南科技大学学报（医学版）》2019年第2期108-110,共3页Journal of Henan University of Science & Technology:Medical Science

基　　金：河南省科技厅科技攻关项目(152102310246)

摘　　要：目的探讨早期肠内营养支持对老年重症肺炎患者的营养状况及T淋巴细胞亚群的影响。方法将82例老年重症肺炎患者随机分为观察组和对照组进行早期肠内营养治疗效果观察。分别于治疗前、治疗后测定:①人体测量学营养指标:肱三头肌皮褶厚度(TSF),上臂肌围(AMC);②采用流式细胞仪测定T淋巴细胞CD^3+、CD^4+、CD^8+水平,并计算CD^4+/CD^8+值;③观察并发症发生情况。结果治疗后,观察组体质指数(22.48±1.88)kg·m^-2,上臂肌围(19.79±1.52)cm,肱三头肌皮褶厚度(1.23±0.21)cm分别低于对照组,差异有统计学意义(P<0.05);CD^3+、CD^4+、CD^4+/CD^8+分别为(77.35±2.65)%、(45.32±3.01)%和(1.89±0.65)%,明显高于对照组的(62.87±2.15)%、(40.97±2.98)%和(1.46±0.41)(P<0.01);CD^8+值为(23.09±1.72)%,低于对照组(26.04±2.82)%,差异有统计学意义(P<0.05);观察组的并发症发生率为5%,低于对照组的21.42%,差异有统计学意义。结论肠内营养支持可以提升老年重症肺炎患者的营养水平,提高免疫功能,可减少并发症的发生。Objective To observe the effect of enteral nutrition support on nutritional level and T-lymphocyte subsets in 82 elderly patients with severe pneumonia. Methods 82 patients were randomly divided into treatment group and control group for early enteral nutrition treatment.The following data were measured before and after treatment:①anthropometric nutritive index:TSF,MAC.②CD^3+,CD^4+ and CD^8+ levels of T-lymphocytes were determined by flow cytometry,and CD^4+/CD^8+ values were calculated.③complications were observed. Results After treatment,body mass index (22.48±1.88) kg·m^-2,AMC(19.79±1.52) cm,TSF (1.23±0.21) cm in treatment group were lower than those of the control group ( P <0.05).CD^3+,CD^4+,and CD^4+/CD 8+ were (77.35±2.65)%,(36.67±3.56)% and (1.44±0.76)%,respectively,which were significantly higher than the control group (62.87±2.15)%,(40.97±2.98)% and (1.46±0.41)( P <0.01).The CD^8+ value was (23.09±1.72)%,which was lower than the control group (26.04±2.82),and the difference was statistically significant ( P<0.05).The incidence of complications 5% in the observation group was lower than that in the control group(21.42%). Conclusion Enteral nutrition support can improve the nutritional level and immune function of elderly patients with severe pneumonia,and reduce the incidence of complications.

关 键 词：肠内营养 老年重症肺炎 肱三头肌皮褶厚度 上臂肌围 T淋巴细胞亚群 并发症 

分 类 号：R459.3[医药卫生—治疗学]