拉莫三嗪联合丙戊酸钠预防卒中后痫性发作的临床有效率分析  

Clinical Efficacy of Lamotrigine Combined with Sodium Valproate in the Prevention of Post-Stroke Epileptic Seizures

作　　者：王国卿[1] 王军[2] 沈象鹏 WANG Guo-qing;WANG Jun;SHEN Xiang-peng(Department of Neurology,Binzhou People's Hospital,Binzhou,Shandong Province,256600 China;Department of Radiology,Binzhou People's Hospital,Binzhou,Shandong Province,256600 China)

机构地区：[1]滨州市人民医院神经内科,山东滨州256600 [2]滨州市人民医院放射科,山东滨州256600

出　　处：《系统医学》2019年第9期75-77,共3页Systems Medicine

摘　　要：目的探讨拉莫三嗪联合丙戊酸钠预防脑卒中继发性癫痫的临床有效率。方法研究对象为2012年3月-2016年4月间符合标准的卒中后痫性发作的高危患者,随机分为两组,即为观察组与不用预防药物(对照组);随访观察2年左右时间,研究对早发痫性发作、迟发痫性发作及癫痫预防作用。结果①两组在基线对比中差异无统计学意义(P<0.05)。②早发型痫性发作及早发癫痫:发病率(χ^2=16.87,P=0.01)、发作时间持续(χ^2=68.51,P=0.01)比较,观察组明显低于对照组,差异有统计学意义;③迟发型痫性发作及癫痫:发病率(χ^2=0.03,P=0.87)、发作时间持续(χ^2=0.14,P=0.74)比较观察组与对照组没有统计学差异;④首次痫性发作时间:观察组卒中后首次癫痫发作间隔时间长于对照组,差异有统计学意义(χ^2=94.12,P=0.01)。结论卒中后痫性发作的高危人群早期、短期应用拉莫三嗪联合丙戊酸钠治疗早发性痫性发作、癫痫较高的预防作用;但对迟发痫性发作及癫痫无预防作用。Objective To investigate the clinical efficacy of lamotrigine combined with sodium valproate in the prevention of stroke-induced epilepsy. Methods High-risk patients with post-stroke seizures who met the criteria from March 2012 to April 2016 were randomly divided into two groups: the observation group and the non-prophylaxis(control group.) Follow-up observation lasted 2 years or so. The prevention of early epileptic seizures, late seizures and epilepsy were studied. Results 1.There was no significant difference between the two groups in the baseline comparison(P <0.05). 2. Early onset seizures and early onset epilepsy: incidence rate(χ^2=16.87, P=0.01), and duration of onset(χ^2=68.51, P= 0.01) of the observation group were significantly lower than those of the control group, there was statistical difference. 3. Late onset seizures and epilepsy: incidence rate(χ^2=0.03, P=0.87), and duration of onset(χ^2=0.14, P=0.74) in the observation group were not statistically different from those in the control group. 4. First epileptic seizure time: The interval between the first epileptic seizures in the observation group was longer than that in the control group,and the difference was a statistically significant(χ^2=94.12, P=0.01). Conclusion Early and short-term use of lamotrigine combined with sodium valproate in the treatment of high-risk episodes of post-stroke seizures has a preventive effect on early onset seizures and epilepsy. However, it has no preventive effect on late seizures and epilepsy.

关 键 词：拉莫三嗪 丙戊酸钠 脑卒中 卒中后痫性发作 卒中后癫痫 

分 类 号：R969.4[医药卫生—药理学]