潘妥拉唑钠注射液对消化性溃疡合并上消化道出血的疗效观察探讨  

Observation on the Efficacy of Pantoprazole Sodium Injection in the Treatment of Peptic Ulcer Complicated with Upper Gastrointestinal Bleeding

作　　者：刘聪[1] LIU Cong(Department of Gastroenterology,Jilin Provincial People's Hospital,Changchun,Jilin Province,130021 China)

机构地区：[1]吉林省人民医院消化内科

出　　处：《系统医学》2019年第9期80-82,共3页Systems Medicine

摘　　要：目的观察消化性溃疡合并上消化道出血采用潘托拉唑钠注射液治疗的疗效。方法选取该院2017年1月-2018年10月收治的消化性溃疡合并上消化道出血患者60例,将其随机分为两组,各30例。两组在原发病治疗、维持水电解质平衡、常规补液等基础上,对照组采用奥美拉唑治疗,观察组采用潘托拉唑钠注射液治疗。比较两组治疗前后胃液pH值、疗效、止血及住院时间、生存质量等情况。结果两组胃液pH治疗前比较无明显差异,而治疗后观察组较对照组显著增高,差异有统计学意义(t=6.935 5,P=0.000)。观察组治疗有效率为93.33%(28/30)较对照组73.33%(22/30)明显较高,差异有统计学意义(χ^2=14.397 7,P=0.000)。在止血及住院时间上,观察组为(2.1±0.8)d、(5.6±2.1)d较对照组(4.8±2.2)d、(12.3±3.4)d显著较短,差异有统计学意义(t=2.324 7,2.125 5,P=0.019,/0.041)。观察组生存质量各项目评分较对照组均显著较高,差异有统计学意义(t=7.345 0,6.676 7,5.726 1,5.849 6,P=0.000)。结论针对消化性溃疡合并上消化道出血采用潘托拉唑钠注射液的疗效非常显著,即可显著改善各种症状,可快速止血,还能提升其胃液pH值,并提升其生存质量,缩短患者住院时间,因此利于患者康复,值得临床应用推广。Objective To observe the efficacy of pantoprazole sodium injection in the treatment of peptic ulcer combined with upper gastrointestinal bleeding. Methods Sixty patients with peptic ulcer complicated with upper gastrointestinal hemorrhage admitted to our hospital from January 2017 to October 2018 were selected and divided into two groups, 30 cases each. The two groups were treated with primary disease treatment, maintenance of water and electrolyte balance, conventional fluid replacement. On the basis of this, the control group received omeprazole treatment,and the observation group received pantoprazole sodium injection. The gastric juice pH, curative effect, hemostasis, hospitalization time and quality of life were compared before after treatment. Results In terms of pH of gastric juice, there was no statistically significant difference between the two groups before treatment. After treatment, the data of the observation group was significant higher than that of the control group. The difference was statistically significant(t=6.935 5 P=0.000). The treatment efficiency of the observation group was 93.33%(28/30), which was higher than the control group(73.33%)(22/30). The difference was statistically significant(χ^2=14.397 7, P=0.000). The hemostasis and hospitalization time of the observation group was(2.1±0.8)d,(5.6±2.1)d, which was significantly shorter than the that of the control group(4.8±2.2)d and(12.3±3.4)d,. The difference of was statistically significant(t=2.324 7,2.125 5,P=0.019,0.041). In terms of quality of life, the scores of each item in the observation group were significantly higher than those in the control group, the difference was statistically significant(t=7.345 0,6.676 7,5.726 1,5.849 6). Conclusion The efficacy of pantoprazole sodium injection for peptic ulcer combined with upper gastrointestinal bleeding is very significant, which can significantly improve various symptoms, the quality of life, and the p H value of gastric juice. Meanwhile, it can quickly quickly stop bleeding, shor

关 键 词：消化性溃疡 上消化道出血 潘托拉唑钠注射液 疗效观察 

分 类 号：R5[医药卫生—内科学]