人工关节置换术后感染的生物治疗方法及前景  

Methods and prospects for biologic treatment of infection after arthroplasty

作　　者：李朔 徐一宏 徐卫东[1] Li Shuo;Xu Yihong;Xu Weidong(Changhai Hospital,Shanghai 200433,China)

机构地区：[1]上海长海医院

出　　处：《中华关节外科杂志（电子版）》2019年第2期213-219,共7页Chinese Journal of Joint Surgery(Electronic Edition)

摘　　要：人工关节假体术后感染是骨科临床治疗的难点、热点。目前假体周围感染(PJI)的治疗方法包括保守治疗和手术治疗,但总的治疗效果不理想。PJI生物治疗是指利用新型杀菌/抑菌剂、生物工程、组织工程等方法,通过破坏生物膜、靶向杀灭致病菌、被动免疫以及局部缓释杀菌剂等方式对PJI进行治疗的新方法。它的出现有望解决PJI治疗存在的一系列难题。本文就近年来PJI生物治疗的研究进展及应用前景进行综述。The treatment of prosthesis joint infection(PJI)is a great challenge in orthopedics.In general,the treatment of PJI includes conservative and surgical therapy,but the overall effect is unsatisfactory.The biotherapy of PJI is a new method to treat PJI by destructing bioflims,specifically killing pathogenic bacteria and activating passive immunity through noval antibiotics,bioengineering,tissue engineering,drug delivery system and other methods.It is expected to solve a series of problems existing in PJI treatment.This article reviewed the progress and application prospect of PJI biotherapy.

关 键 词：人工关节 感染 生物疗法 

分 类 号：R687.4[医药卫生—骨科学]