山蜡梅叶化学成分研究(Ⅱ)  

Chemical Constituents from the Leaves of Chimonanthus nitens(Ⅱ)

作　　者：姚瑶 黄赞兴 舒任庚 万怡莉 张敏 YAO Yao;HUANG Zan-xing;SHU Ren-geng;WAN Yi-li;ZHANG Min(School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院

出　　处：《中药材》2019年第1期100-102,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(81360631)

摘　　要：目的:研究山蜡梅叶的化学成分。方法:采用硅胶柱色谱、MCI柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备高效液相色谱等方法进行分离纯化,根据化合物理化性质及光谱数据鉴定结构。结果:从山蜡梅叶中分离得到9个化合物,分别鉴定为:(S)-3-羟基-β-紫罗兰酮(1)、CPC-2(2)、6,7-二甲氧基香豆素(3)、山柰酚(4)、(E)-2,7-dimethyloct-4-enedioic acid(5)、1,3,5-trimethoxybenzene(6)、东莨菪内酯(7)、(4S)-4-hydroxyl-1,10-seco-muurol-5-ene-1,10-dione(8)、对羟基苯甲酸(9)。结论:其中,化合物1、2、5、6、8为首次从该植物中分离得到,化合物1、5、6为首次从该属植物中分离得到。Objective:To study the chemical constituents from the leaves of Chimonanthus nitens. Methods:The compounds were isolated and purified by column chromatography on silica gel,MCI,ODS,Sephadex LH-20,semi-preparative HPLC and so on. The structure were identified by physicochemical properties and spectral datum. Results:Nine compounds were obtained and identified as(S)-3-hydroxyl-β-ionone(1),CPC-2(2),6,7-dimethoxycoumarin(3),kaempferol(4),(E)-2,7-dimethyloct-4-enedioic acid(5),1,3,5-trimethoxybenzene(6),scopoletin(7),(4S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione(8),4-hydroxybenzoic acid(9). Conclusion:Compounds 1,2,5,6,8 are isolated from this plant for the first time and compounds 1,5,6 are isolated from this genus for the first time.

关 键 词：山蜡梅 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]