单磷酸阿糖腺苷水分测定法的改进  

Improvement of the moisture determination of Vidarabine monophosphate

作　　者：梁改玲[1] 李洁[1] 全巧玲 LIANG Gailing;LI Jie;QUAN Qiaoling(Henan Provincial Institute of Food and Drug Control,Zhengzhou,Henan,450018 P.R.China;Hami Institute of Food and Drug Control,Hami,Xinjiang,839000 P.R.China)

机构地区：[1]河南省食品药品检验所,河南郑州450018 [2]新疆哈密市食品药品检验所,新疆哈密839000

出　　处：《华西药学杂志》2019年第3期291-293,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的改进国家药品标准中单磷酸阿糖腺苷水分测定的方法。方法以10%咪唑无水甲醇为溶剂,采用容量滴定法,用水分测定仪滴定费休氏试液至终点。结果3~15 mg含水量与消耗滴定液的体积呈良好的线性关系(r=0.9971),平均回收率为98.6%(n=9)。结论所用方法稳定、准确、可靠,可用于单磷酸阿糖腺苷的水分测定。OBJECTIVE To improve the method for the determination of water content of Vidarabine monophosphate in National Drug Standard.METHODS The solvent was 10%imidazole methanol anhydrous.Titrate Karl Fischer reagent to the end point with a moisture analyze by Volumetic titration.RESULTS The linearity was obtained over 1-15 mg of purified water(r=0.9971).The average recovery of the method was 98.6%(n=5).CONCLUSION This method is simple and rapid.It can be used for the water determination of Vidarabine monophosphare.

关 键 词：单磷酸阿糖腺苷 费休氏法 费休氏试液 咪唑 无水甲醇 水分测定仪 容量滴定法 质量控制 

分 类 号：R917[医药卫生—药物分析学]