马来酸麦角新碱联合缩宫素预防二次剖宫产产后出血的效果分析  

Effect analysis of ergonovine maleate combined with oxytocin in preventing postpartum hemorrhage after second cesarean section

作　　者：魏凌燕 王海霞 WEI Ling-yan;WANG Hai-xia(Department of Obstetrics and Gynecology,Guangdong Zhongshan Dongfeng People's Hospital,Zhongshan 528425,China)

机构地区：[1]广东省中山市东凤人民医院妇产科

出　　处：《中国实用医药》2019年第16期4-6,共3页China Practical Medicine

摘　　要：目的分析马来酸麦角新碱联合缩宫素预防二次剖宫产产后出血的效果。方法 60例二次剖宫产分娩产妇,以随机数字表法分为常规组和观察组,各30例。常规组单用缩宫素,观察组联用马来酸麦角新碱与缩宫素。比较两组产妇的产后出血情况、血红蛋白水平、出血量、应用其他促宫缩药物情况、用药后不良反应发生情况。结果观察组产后出血率为6.67%,低于常规组的30.00%,差异具有统计学意义(P<0.05)。两组产前、产后24 h血红蛋白水平比较,差异均无统计学意义(P>0.05)。观察组术中、术后2 h、术后2~24 h的出血量分别为(277.65±99.57)、(99.85±82.67)、(42.47±27.19)ml,均少于常规组的(402.17±154.32)、(139.71±62.87)、(82.32±40.09)ml,差异均具有统计学意义(P<0.05)。常规组中有11例(36.67%)产妇应用了其他促宫缩药物,观察组中有3例(10.00%)产妇应用了其他促宫缩药物,观察组其他促宫缩药物应用率低于常规组,差异具有统计学意义(χ^2=5.963, P<0.05)。观察组产妇用药后的不良反应发生率为53.33%,与常规组的50.00%比较,差异无统计学意义(P>0.05)。结论联合应用马来酸麦角新碱、缩宫素预防二次剖宫产产后出血的效果更加明显,安全有效,值得推广。Objective To analyze the effect of ergonovine maleate combined with oxytocin in preventing postpartum hemorrhage after second cesarean section. Methods A total of 60 parturients with second cesarean section were divided into conventional group and observation group by random number table method, with 30 cases in each group. The conventional group was received oxytocin, and the observation group received ergonovine maleate combined with oxytocin. Comparison were made on postpartum hemorrhage, hemoglobin levels, bleeding volume, application of other uterine contraction-promoting drugs and occurrence of adverse reactions after medication between the two groups. Results The observation group had lower postpartum hemorrhage rate as 6.67% than 30.00% in conventional group, and the difference was statistically significant (P<0.05). Both groups had no statistically significant difference in prenatal and postpartum 24 h hemoglobin levels (P>0.05). The observation group had less bleeding volume during operation, 2 h after operation and 2~24 h after operation were respectively as (277.65± 99.57),(99.85 ± 82.67) and (42.47± 27.19) ml than (402.17 ± 154.32),(139.71 ± 62.87) and (82.32 ± 40.09) ml in the control group. Their difference was statistically significant (P<0.05). The conventional group had 11 cases (36.67%) with other uterine contraction-promoting drugs, while the observation group had 3 cases (10.00%) with other uterine contraction-promoting drugs. The observation group had lower application rate of other uterine contraction-promoting drugs than conventional group, and the difference was statistically significant (X^2=5.963, P<0.05). The observation group had no statistically significant difference in incidence of adverse reactions after medication as 53.33%, comparing with 50.00% in conventional group (P>0.05). Conclusion The combined application of ergonosine maleate and oxytocin in the prevention of postpartum hemorrhage after second cesarean section is more obvious, safe and effective, and worthy of prom

关 键 词：马来酸麦角新碱 缩宫素 二次剖宫产术 产后出血 

分 类 号：R719.8[医药卫生—妇产科学]