可降解纳米氧化钇空心球载药体系的体外抗肿瘤效应  

In vitro anticancer effect of degradable nano-yttrium oxide hollow sphere drug delivery system

作　　者：韩宇 张芳波 于林康 贾光[1] 葛昆[1] HAN Yu;ZHANG Fangbo;YU Linkang;JIA Guang;GE Kun(Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China)

机构地区：[1]河北大学化学与环境科学学院药物化学与分子诊断教育部重点实验室河北省化学生物学重点实验室

出　　处：《河北大学学报（自然科学版）》2019年第4期366-371,378,共7页Journal of Hebei University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(21807023);河北省创新项目(CXZZSS2018156);河北大学创新项目(hbu2019ss006)

摘　　要：纳米氧化钇空心球在生物医学领域具有广泛的应用.以酚醛树脂微球为模板,合成出了尺寸均一、分散性好的纳米Y2O3空心球(HYNPs).它不仅在体外表现出显著的酸性降解行为,而且负载抗肿瘤药物阿霉素(DOX)后,载药体系HYNPs-DOX也表现出明显的pH响应药物释放特点.pH为5.0时,72h的药物释放可达到70.46%;而pH为7.4时,72h的药物释放仅25.04%.进一步通过激光共聚焦显微镜监测载药体系在细胞内的DOX释放,发现随着时间的延长,细胞内DOX的荧光逐渐增加,表明DOX在细胞内释放量的增加.体外抗肿瘤细胞毒性结果显示,HYNPs对肿瘤细胞MCF-7和MDA-MB-231的活性没有影响,而HYNPs-DOX则表现出较高的体外抗肿瘤效应,与游离DOX相当.可见,该材料作为抗肿瘤药物载体具有潜在的应用价值.Nano-yttrium oxide hollow sphere has broad application in the field of biological medicine.The uniform and well-dispersed Y2O3 hollow spheres (HYNPs) have been fabricated using phenolic resin spheres as template.The HYNP snot only exhibited a high DOX loading and release efficiency, but also showed the pH-sensitive degradableand drug release profiles. And the DOX release from the HYNPs-DOX in the cells increased with time. Moreover, the low cytotoxicity of HYNPs was found on MCF-7and MDA-MB-231 cells. When loaded with DOX, HYNPs-DOX exhibited a good anticancer efficiency in vitro , which showed a great potential in cancer treatment.

关 键 词：氧化钇纳米颗粒 中空球形 载药 释药 抗肿瘤 

分 类 号：O61[理学—无机化学]