高迁移率族蛋白1与心血管疾病相关性的研究进展  

Research progress of correlation between high mobility group box 1 and cardiovascular diseases

作　　者：阚福强 聂宏刚[1] KAN Fu-qiang;NIE Hong-gang(Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科

出　　处：《心血管康复医学杂志》2019年第3期379-382,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：高迁移率族蛋白1(HMGB1)是由凋亡细胞和单核细胞/巨噬细胞释放,通过与其相应的受体结合在介导炎症的发展和促进组织的修复和再生中起到重要作用的。近年来一些研究表明HMGB1在冠心病、心力衰竭、心肌损伤等方面有重要的诊断和预后评估价值。本文总结了近年来HMGB1在心血管疾病中的研究进展。High mobility group box 1 (HMGB1) protein is released by apoptotic cells and monocytes/macrophages. It plays an important role in mediating inflammation development and promoting tissue repairment and regeneration via combining with corresponding receptors. In recent years, some researches indicated that HMGB1 possessed important diagnostic and prognostic assessment value for coronary heart disease, heart failure and myocardial injury etc. The present article summarized research progress of HMGB1 in cardiovascular diseases in recent years.

关 键 词：心血管疾病 高迁移率族蛋白类 动脉粥样硬化 

分 类 号：R5409[医药卫生—心血管疾病]