血清25-羟维生素D的水平变化与皮肌炎相关肺间质病变的相关性分析  

Correlation Analysis of Serum Levels of 25-hydroxyvitamin D and Dermatomyositis-associated Pulmonary Interstitial Diseases

作　　者：梁志强 裴银辉[1] 庞桂芬 张勃[2] 姜凤云[2] 张庆[2] 郝长来[2] LIANG Zhiqiang;PEI Yinhui(The North China University of Science and Technology, Hebei Tangshan 06300, China)

机构地区：[1]华北理工大学基础医学院,河北唐山063000 [2]承德医学院附属医院,河北承德067000

出　　处：《河北医学》2019年第6期953-955,共3页Hebei Medicine

基　　金：河北省承德市科学技术研究与发展计划项目,(编号:201701A052)

摘　　要：目的:探讨血清25-羟维生素D(25OH-D)的水平变化与皮肌炎相关肺间质病变(DM-ILD)的相关性。方法:选择2015年3月至2017年2月于我院风湿科就诊的81例DM-ILD患者作为研究对象(研究组),以同期就诊的82例DM患者和80例健康志愿者分别作为对照组和健康对照组,采用高效液相色谱-串联质谱法分别检验各组血清25OH-D水平,分析25OH-D水平在各组之间的差异。结果:研究组血清25OH-D水平均明显低于对照组和健康对照组,差异具有统计学意义(P<0.01);对照组血清25OH-D水平明显低于健康对照组,差异具有统计学意义(P<0.05);研究组中血清25OH-D水平非正常患者为97.53%明显高于对照组的43.90%(P=0.035),且研究组中血清25OH-D水平处于"严重缺乏"和"缺乏"患者的比例明显高于对照组(P<0.05)。结论:DM-ILD患者血清25OH-D偏低与DM-ILD具有密切的关系,对DM-ILD的诊断具有一定临床价值。Objectives: To investigate the correlation between serum levels of 25-hydroxyvitamin D (25OH-D) and dermatomyositis-associated pulmonary interstitial disease (DM-ILD). Methods: 81 cases of DM-ILD were selected from March 2016 to February 2017 in our hospital department of rheumatism in our hospital as the research object (research group), 82 DM patients and 80 healthy volunteers were selected as control group and healthy-control group in the same period. The serum levels of 25OH-D in each group were tested by the method of high performance liquid chromatography combined with tandem mass spectrometry.And the differences of 25OH-D levels among the groups were analyzed. Results: The serum levels of 25OH-D in research group was significantly lower than the control group and healthy-control group, and the difference were statistically significant (P<0.01). The serum level of 25OH-D in the control group was significantly lower than that in healthy control group, and the difference were statistically significant (P<0.05). The serum level of 25OH-D in research group was 97.53% which was significantly higher than that in the control group (43.90%)(P=0.035).The proportions of patients with 'severely deficient' or 'lack' of 25OH-D serum levels in research group were significantly higher than that in control group (P<0.05). Conclusions: The lower serum level of 25OH-D in patient with DM-ILD is closely related with DM-ILD, and it has a certain clinical value for the early diagnosis of DM-ILD.

关 键 词：25-羟维生素D 皮肌炎相关肺间质病变 相关性 

分 类 号：R593.26[医药卫生—内科学] R563[医药卫生—临床医学]