坤复康胶囊改善盆腔炎性疾病后遗症患者子宫微循环、炎症细胞浸润的临床效果  

Research on the effect of Kunfukang capsule on improving Uterine Microcirculation in patients with sequelae of pelvic inflammatory disease and its influence on levels of CRP,GMCSF and MCP-1in peripheral blood

作　　者：丁燕燕[1] 王昊珏 DING Yan-yan;WANG Hao-jue(Rugao People's Hospital, Department of Obstetrics and Gynecology, Rugao, Jiangsu Province, 226500, China;Wuxi Xishan People's Hospital, Department of Obstetrics and Gynecology, Wuxi, Jiangsu Province, 214000, China)

机构地区：[1]如皋市人民医院妇产科,江苏如皋226500 [2]无锡市锡山人民医院妇产科,江苏无锡214000

出　　处：《海南医学院学报》2019年第12期935-939,共5页Journal of Hainan Medical University

基　　金：无锡市卫生计生委科研项目(MS201608)~~

摘　　要：目的:观察坤复康胶囊改善盆腔炎性疾病后遗症患者子宫微循环的效果及对外周血C反应蛋白(c-reactive protein,CRP)、粒细胞-巨噬细胞集落刺激因子(Granulocyte macrophage-colony stimulating factor,GM-CSF)、单核细胞趋化蛋白-1(monocyte chemokinin-1,MCP-1)水平的影响。方法:选择我院收治的126例盆腔炎性疾病后遗症患者,随机分为对照组和观察组各63例。对照组给予阿奇霉素片口服;观察组在对照组基础上加用坤复康胶囊内服,7 d为1个疗程,连续治疗4个疗程。比较两组治疗的临床效果,评价中医证候积分,观察子宫微循环及外周血CRP、GM-CSF、MCP-1水平,记录治疗过程中患者的不良反应。结果:观察组的有效率明显高于对照组(P<0.05);观察组治疗后的中医证候总积分则较对照组明显降低(P<0.05);子宫微循环改善更明显,PI、RI均较对照组明显降低,Vs、Vd、Vm则较对照组升高(P<0.05);外周血CRP、GM-CSF、MCP-1水平明显低于对照组(P<0.05);治疗过程中,观察组不良反应发生率明显低于对照组(P<0.05)。结论:坤复康胶囊联合阿奇霉素利于缓解盆腔炎性疾病后遗症患者的临床症状,其机制可能与改善患者子宫微循环状态及抑制外周血CRP、GM-CSF、MCP-1水平以减轻盆腔组织的炎性浸润有关,用药安全可靠。Objective: To investigate the clinical effect of Kunfukang capsule on improving uterine microcirculation in patients with sequelae of pelvic inflammatory disease, and to observe its influence on levels of CRP, GM-CSF and MCP-1 in peripheral blood. Methods: 126 patients with pelvic inflammatory disease sequelae admitted to our hospital from January 2017 to June 2018 were selected and divided into control group and observation group with 63 cases in each group according to the random number table method. Patients in the control group were given azithromycin tablets orally, while patients in the observation group were treated with Kunfukang capsule on the basis of control group,7days for a course of treatment, 4 courses of continuous treatment. The purpose of this study was to compare the clinical effects of treatment between the two groups, evaluate the TCM syndrome score, observe the levels of CRP, GM-CSF and MCP-1 in uterine microcirculation and peripheral blood, and record the adverse reactions of patients during treatment. Results: The effective rate of 90.48% in the observation group was significantly higher than that in the control group of 77.78%( P <0.05). After treatment, the total score of TCM syndromes was significantly lower than that in the control group ( P <0.05). The improvement of uterine microcirculation was more obvious, and the PI and RI were significantly decreased compared with the control group, while Vs, Vd and Vm were increased compared with the control group ( P <0.05). The levels of CRP, GM-CSF and MCP-1 in peripheral blood were significantly lower than those in the control group ( P <0.05). During the treatment, the adverse reaction rate of 7.94% in the observation group was significantly lower than that of the control group of 25.40%( P <0.05). Conclusion: Kun fu kang capsule combined with azithromycin is beneficial to reduce pelvic mass in sequelae of pelvic inflammatory disease and alleviate clinical symptoms. The mechanism may be related to improving the status of uterine microcircul

关 键 词：盆腔炎性疾病后遗症 坤复康胶囊 子宫微循环 CRP GM-CSF MCP-1 

分 类 号：R711.33[医药卫生—妇产科学]