辣木叶改善睡眠复方颗粒剂成型工艺研究  

Optimal Molding Technology of Compound Formula of Moringa Oleifera to Improve Sleep

作　　者：李梦薇[1] 顾文宏 温浩然 尹济云 韩星 冀艳华 刘洋[1] LI Mengwei;GU Wenhong;WEN Haoran;YIN Jiyun;HAN Xing;JI Yanhua;LIU Yang(School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;Yunnan Tianyou Technology Development Co., Ltd., Mangshi 678400, China)

机构地区：[1]北京中医药大学中药学院,北京100102 [2]云南天佑科技开发有限公司,云南芒市678400

出　　处：《中医药学报》2019年第3期67-70,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金面上项目(81274042)

摘　　要：目的:筛选出辣木叶改善睡眠复方颗粒剂的最佳成型工艺条件。方法:考察不同类型的辅料(乳糖、甘露醇、糊精、麦芽糊精、可溶性淀粉)对辣木叶改善睡眠复方颗粒成型的影响,以制备颗粒剂的成型性、溶解性、流动性及抗吸湿性作为考察的关键粉体学性质指标综合评价,优选出辣木叶改善睡眠复方颗粒剂的最佳处方及成型工艺。结果:辣木叶改善睡眠复方颗粒浸膏粉采用湿法制粒时优选出的辅料为乳糖,其最佳处方组成为浸膏粉∶乳糖=1∶ 1制粒,按此比例所制的颗粒成型性、溶解性及流动性均良好且不易吸湿,较为理想。结论:该颗粒剂所选辅料合理,成型制备工艺简便可行,为进一步颗粒剂质量评价及工业化生产奠定基础。Objective: To select the optimal molding technology for compound formula of Moringa Oleifera to improve sleep. Methods: With particles of formability, liquidity, dissolubility, mobility and anti-moisture absorption as key assessment indexes, the influence of different excipients, including lactose, mannitol, dextrine, maltodextrin and soluble amylum, on the compound formula of Moringa Oleifera to improve sleep were investigated to select the best molding technology by adopting a comprehensive scoring method. Results: Lactose is the best excipient for the compound formula of Moringa Oleifera to improve sleep. The dry extract powder to lactose ratio is 1∶ 1. According to this proportion, the obtained granules were ideal. Conclusion: The selected excipient is suitable, the optimal condition is simple and convenient, which lays the foundation for further quality evaluation of granule and industrialized large-scale production.

关 键 词：辣木叶改善睡眠复方 颗粒剂 成型工艺 

分 类 号：R283.6[医药卫生—中药学]