TiO2纳米管阵列/介孔羟基磷灰石复合型药物载体的构建及药物缓释研究  

Construction and drug sustained release of TiO2 nanotube array/mesoporous hydroxyapatite composite drug carrier

作　　者：郑竑 陈学生 林伟[1] ZHENG Hong;CHEN Xuesheng;LIN Wei(Department of Orthopaedics,Fuzhou Municipal Second Hospital, Fuzhou,Fujian 350007,China)

机构地区：[1]福建省福州市第二医院骨科

出　　处：《福建医药杂志》2019年第3期8-11,共4页Fujian Medical Journal

基　　金：2018年福建省自然科学基金面上项目(2018J01357)

摘　　要：目的构建一种骨科钛板表面TiO2纳米管阵列/介孔羟基磷灰石(m-HA)复合型药物载体,考察阿仑膦酸钠(ALN)在其上的缓释性能。方法利用X射线衍射(XRD)、扫描电镜(SEM)、透射电镜(TEM)分别表征TiO2纳米管阵列及TiO2纳米管阵列/m-HA复合型药物载体的形貌,并测定其上负载ALN的缓释。结果成功构建了稳定的TiO2纳米管阵列/m-HA复合型药物载体,相对于TiO2纳米管阵列具有更大的药物担载量。同时负载在TiO2纳米管阵列中的ALN在第3d时释放量即达(88.06±6.27)%,从第5d开始,药物释放基本完毕,8d后的总释放率为(94.91±8.51)%;负载在TiO2纳米管阵列/m-HA复合型药物载体中的ALN在第3d时的释放量仅为(66.51±5.37)%,且在后续的几天里保持持续缓慢释放药物,8d后总释放率达到(97.31±8.22)%。结论 TiO2纳米管阵列/m-HA复合型药物载体比单纯的TiO2纳米管阵列具有更大的药物担载量,同时缓释性能更好。Objective To construct a TiO2 nanotube array/mesoporous hydroxyapatite(m-HA)composite drug carrier on the surface of orthopedic titanium plate,and investigate the sustained release of alendronate sodium(ALN)on its performance.Methods X-ray diffraction(XRD),scanning electron microscopy(SEM)and transmission electron microscopy(TEM)were used to characterize the morphology of TiO2 nanotube array and TiO2 nanotube array/m-HA composite drug carriers.The sustained release of the loaded ALN was measured.Results Stable TiO2 nanotube array/m-HA composite drug carriers were successfully constructed,which had a larger drug loading capacity than the TiO2 nanotube array.The release rate of ALN loaded on the TiO2 nanotube array at the 3 rd days was(88.06±6.27)%,the drug release was almost completed from the 5 th day,and the total release rate after eight days was(94.91±8.51)%.The release rate of ALN loaded on the TiO2 nanotube array/m-HA composite drug carriers was only(66.51±5.37)% at the 3 rd days,the sustained release of the drug continued for the next few days,and the total release rate reached(97.31±8.22)% after eight days.Conclusion The TiO2 nanotube array/m-HA composite drug carrier has a larger drug loading than the pure TiO2 nanotube array,and the sustained release performance is better.

关 键 词：骨科钛板 TIO2纳米管阵列 介孔羟基磷灰石 阿仑磷酸钠 缓释 

分 类 号：R68[医药卫生—骨科学]