贵阳市40岁及以上男性肝脏酶学与血清LDL-C水平关系的横向研究  

A cross-sectional study of the relationship between Liver Enzyme and serum LDL-C level in Men aged Forty and Elderly in Guiyang

作　　者：刘丹 张巧 张淼 彭年春 胡颖 时立新 Liu Dan;Zhang Qiao;Zhang Miao;Peng Nianchun;Hu Ying;Shi Lixin(Department of Endocrinology and metabolic diseases,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学附属医院内分泌代谢病科

出　　处：《贵州医药》2019年第6期854-857,865,共5页Guizhou Medical Journal

基　　金：上海交通大学医学院附属瑞金医院“2型糖尿病危险因素的动态监测与社区综合防治”(编号:201502007);贵州省科学技术厅项目[编号:黔科合LH字(2015)7413号];贵州省临床重点专培育项目(医政:S2D-2016-01)

摘　　要：目的探讨贵阳市40岁及以上男性肝脏酶学与血清LDL-C水平及分层的关系。方法选取贵阳市云岩区居住5年以上、年龄≥40岁的常驻居民共10140名,其中男性2697名,检测丙氨酸转氨酶(ALT)、γ-谷氨酰转肽酶(GGT)、天门冬氨酸转氨酶(AST)水平、低密度脂蛋白胆固醇(LDL-C)等血清学指标。对肝酶进行四分位分组,采用多元Logistic回归分析不同肝酶水平与血清LDL-C水平及分层之间的关系。结果多元Logistic回归分析表明,校正了相关危险因素后,ALT、AST、GGT水平最高组LDL-C边缘升高风险均增加、LDL-C升高风险均增加、LDL-C理想水平可能性降低;LDL-C合适水平可能性增加(P均<0.05)。结论在贵阳市年龄≥40岁的中老年男性人群中,血清ALT、AST、GGT水平与血清LDL-C水平关联,血清ALT、AST、GGT水平升高者血清LDL-C边缘升高、LDL-C升高水平的风险增加,而血清LDL-C理想水平的可能性降低,血清AST、GGT水平过高或过低LDL-C合适水平的可能性均下降。Objective To investigate the relationship between liver enzymes and serum LDL-C levels and their stratification in male aged 40 and elderly in Guiyang.Methods A total of 10140 residents aged 40 and over who lived in Yunyan District of Guiyang cIty form of ethan 5 years were selected from May to October 2011,among them,2697 were males,with serum alanine aminotransferase (ALT),gamma-glutamyl transpeptidase (GGT),aspartate aminotransferase (AST),blood low density lipoprotein cholesterol (LDL-C) and other serological indexes.The liver enzymes were divided into four groups and the relationship between the levels of liver enzymes and serum LDL-C was analyzed by multiple logistic regression.Results After adjusting relevant risk factors by multiple logistic regression analysis,the risk of the marginal elevation of serum LDL-C in the highest level of ALT、AST、GGT group、 the risk of the elevation of serum LDL-C increased、the possibility of the ideal level of serum LDL-C decreased;the possibility of the appropriate level of serum LDL-C increased( P 均<0.05).Conclusion Serum ALT,AST and GGT levels correlated with serum LDL-C levels among the middle-aged and elderly males aged 40 years and above in Guiyang.The risk of the marginal elevation of serum LDL-C and elevation of serum LDL-C increased in those with elevated serum ALT,AST and GGT levels,while the possibility of the ideal level of serum LDL-C decreased.However,when the level of serum AST and GGT was too high or too low,the possibility of the appropriate level of serum LDL-C decreased.

关 键 词：丙氨酸转氨酶 Γ-谷氨酰转肽酶 天门冬氨酸转氨酶 低密度脂蛋白胆固醇 

分 类 号：R333.4[医药卫生—人体生理学]