晚期早产儿早期神经系统发育情况及其影响因素  

Early neurological development analysis in late preterm infants and its influencing factors

作　　者：龙芳[1] 邹静静[1] 钟迪[1] 陈露雨[2] LONG Fang;ZOU Jing-jing;ZHONG Di;CHEN Lu-yu(Department of Neonatology, Guangdong Maternal and Child Health Hospital, Guangzhou 510010, Guangdong, CHINA;Department of Internal Medicine , Guangdong Maternal and Child Health Hospital, Guangzhou 510010, Guangdong, CHINA)

机构地区：[1]广东省妇幼保健院新生儿科,广东广州510010 [2]广东省妇幼保健院内科,广东广州510010

出　　处：《海南医学》2019年第12期1551-1553,共3页Hainan Medical Journal

基　　金：广东省科技计划项目立项资助项目(编号:2014A020213011)

摘　　要：目的探讨晚期早产儿早期神经系统发育情况及其影响因素。方法选取广东省妇幼保健院产科2015年6月至2016年5月出生的150例晚期早产儿为研究对象(晚期组),通过多种因素配对后,选取同期150例足月儿作为对照(足月组)。于晚期早产儿矫正胎龄40周、6个月龄以及1周岁时三个时间点对两组儿童进行智能测试,比较晚期组和足月组智能发育水平。根据上述智能测试结果将晚期组分为发育正常组和发育异常组,分析影响神经系统发育的危险因素。结果晚期组和足月组在矫正胎龄40周、6个月龄和1周岁纳入随访者分别为150例、142例、135例和150例、127例、115例;6个月龄晚期组早产儿大运动明显落后于足月儿,1周岁时大运动、精细运动和语言均落后于足月儿,差异均有统计学意义(P<0.05);多因素分析结果显示,小于胎龄、低血糖、Apgar评分、败血症、新生儿呼吸窘迫综合征和父母文化程度低是影响晚期早产儿早期发育的危险因素(P<0.05)。结论晚期早产儿早期神经系统发育落后于足月儿,小于胎龄、新生儿呼吸窘迫综合征、低血糖、Apgar评分、败血症和父母文化程度低是影响晚期早产儿早期神经系统发育的危险因素。Objective To explore the early development of nervous system in late preterm infants and its influencing factors. Methods A total of 150 late preterm infants born in the Department of Obstetrics, Guangdong Maternal and Child Health Hospital from June 2015 to May 2016 were selected as subjects(late group), and, after pairing with various factors, 150 full-term children were selected as controls(full-term group). Intelligent tests were performed in the two groups at 40 weeks, 6 months and 1 year of corrected age, and the intelligence development levels of the late group and the full-term group was compared. According to the above intelligent test results, the late group were further divided into the normal development group and the dysplastic group, and the risk factors affecting the development of the nervous system were analyzed. Results A total of 150, 142, 135 late preterm infants were assessed at 40 weeks, 6 months and 1 year of corrected age, respectively. Meanwhile, 150, 127 and 115 full-term infants were also evaluated in the corresponding time. At corrected age of 6 months, the development of gross motor skills in the late group were lagging behind their peers of full-term birth;at corrected age of 1 year, the development of gross motor skills, fine motor skills, and language skills in late preterm infants remain lagging behind full-term infants, and the differences were both statistically significant(P<0.05). Multivariate analysis showed that less than gestational age, hypoglycemia, Apgar score, sepsis, neonatal respiratory distress syndrome, and low parental education were risk factors for early development of the nervous system in late preterm infants(P<0.05). Conclusion In the early stage of late preterm infants, the development of the nervous system lags behind full-term children. Less than gestational age, neonatal respiratory distress syndrome, hypoglycemia, Apgar score, sepsis, and low parental education are risk factors for the development of early advanced nervous system in late preterm infants.

关 键 词：晚期早产儿 足月儿 神经系统发育 危险因素 干预措施 

分 类 号：R722[医药卫生—儿科]