中药经验方治疗脾肾阴虚型2型糖尿病疗效观察  

Treatment of type 2 diabetes mellitus with spleen and kidney Yin deficiency by experienced prescription of traditional Chinese medicine

作　　者：黄爱招[1] 周冰峰[2] 李慧 HUANG Ai-zhao;ZHOU Bing-feng;LI Hui(Ministry of Pharmacy, Huizhou Central People's Hospital, Guangdong Province, Huizhou 516001, Guangdong, CHINA;Department of Rehabilitation Medicine, Huizhou Central People's Hospital, Guangdong Province, Huizhou 516001, Guangdong, CHINA)

机构地区：[1]惠州市中心人民医院药学部,广东惠州516001 [2]惠州市中心人民医院康复医学科,广东惠州516001

出　　处：《海南医学》2019年第12期1581-1583,共3页Hainan Medical Journal

摘　　要：目的探讨应用中药经验方治疗脾肾阴虚型2型糖尿病的临床疗效。方法将惠州市中心人民医院康复医学科2017年1月至2018年6月收治的200例脾肾阴虚型2型糖尿病患者以随机数表法分为观察组和对照组,每组100例,对照组采用常规应用二甲双胍治疗,而观察组在对照组的用药基础上,为患者加用中药经验方治疗,治疗4周后比较两组患者的治疗效果、血糖指标变化及不良反应发生情况。结果观察组患者的治疗总有效率为93.0%,明显高于对照组的68.0%,差异有统计学意义(P<0.05);治疗4周后,观察组和对照组患者的空腹血糖(FBG)分别为(4.56±0.87)mmol/L、(6.12±0.96)mmol/L,低于治疗前的(7.21±1.32)mmol/L和(7.24±1.29)mmol/L,差异均有统计学意义(P<0.05);两组患者治疗后的餐后2 h血糖(2 hPG)分别为(8.12±1.56)mmol/L、(9.84±1.77)mmol/L,明显低于治疗前的(12.07±1.85)mmol/L和(12.04±1.83)mmol/L,差异均有统计学意义(P<0.05);两组患者治疗后的糖化血红蛋白(HbAlc)分别为(4.88±0.67)%和(6.13±0.84)%,明显低于治疗前的(7.65±1.17)%、(7.62±1.14)%,差异均有统计学意义(P<0.05);治疗后观察组的上述三项指标水平降低幅度较对照组显著,差异均有统计学意义(P<0.05);治疗期间两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论在常规使用胰岛素用药治疗的基础上加用中药经验方治疗脾肾阴虚型2型糖尿病可有效控制患者血糖,且治疗期间患者不良反应发生率也较低,临床治疗效果显著,值得临床推广。Objective To explore the effect of experienced prescription of traditional Chinese medicine on type 2 diabetes mellitus with deficiency of spleen and kidney Yin deficiency. Methods Two hundred patients with type 2 diabetes mellitus of deficiency of spleen and kidney Yin deficiency were randomly divided into observation group(n=100)and control group(n=100) according to the random number table. The control group was treated with Metformin, while the observation group was treated with empirical prescription of traditional Chinese medicine on the basis of the medication of the control group. The therapeutic effect, blood sugar index changes, and adverse effects of the two groups were observed. Results The total effective rate of observation group was 93.00%, which was significantly higher than 68.00% of control group(P<0.05). After four weeks of treatment, the fasting blood glucose(FBG) of observation group and control group were(4.56±0.87) mmol/L,(6.12±0.96) mmol/L, which was significantly lower than(7.21±1.32) mmol/L and(7.24±1.29) mmol/L before treatment(P<0.05). The two-hour postprandial glucose(2 hPG) was(8.12±1.56) mmol/L,(9.84±1.77) mmol/L respectively, which were significantly lower than(12.07±1.85) mmol/L and(12.04±1.83) mmol/L before treatment(P<0.05). The HbAlc of the two groups after treatment was(4.88±0.67)% and(6.13±0.84)%, which were significantly lower than(7.65±1.17)% and(7.62±1.14)% before treatment. After treatment, the levels of the above three indicators in the observation group were significantly lower than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion For type 2 diabetes mellitus with spleen and kidney Yin deficiency, applying experienced prescription of traditional Chinese medicine on the basis of routine insulin therapy can achieve remarkable curative effect, effectively control the blood sugar, and reduce the incidence of adverse reactions during treatment, which is worthy of

关 键 词：中药经验方 脾肾阴虚型 2型糖尿病 临床疗效 血糖 

分 类 号：R587.1[医药卫生—内分泌]