HA、Ⅳ-C、APRI及Fib-4对乙型肝炎后肝纤维化的诊断效果  

Roles of HA,Ⅳ-C,APRI and Fib-4 in the diagnosis of hepatitis B-related liver fibrosis

作　　者：俞晓春 胡旭姣 章家青 国蕾蕾 YU Xiaochun;HU Xujiao;ZHANG Jiaqing;GUO Leilei(Department of Clinical Laboratory,the First Hospital of Ninghai County,Ninghai 315600,Zhejiang,China;Department of Clinical Laboratory,Yinzhou People's Hospital of Ningbo City,Ningbo 315040,Zhejiang,China)

机构地区：[1]宁海县第一医院检验科,浙江宁海315600 [2]宁波市鄞州人民医院检验科,浙江宁波315040

出　　处：《检验医学》2019年第6期539-542,共4页Laboratory Medicine

摘　　要：目的分析乙型肝炎后肝纤维化患者的透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、天门冬氨酸氨基转移酶(AST)/血小板(PLT)比值(APRI)以及纤维蛋白原(Fib)-4对乙型肝炎后肝纤维化的诊断效果。方法选取乙型肝炎患者320例,记录患者年龄、性别等信息。根据Metavir评分系统分级。采用化学发光法检测患者血清样本的HA、Ⅳ-C,计算APRI及Fib-4,采用受试者工作特征(ROC)曲线对4个指标的诊断效果进行评估。结果 HA、Ⅳ-C、APRI及Fib-4与肝纤维化分期呈正相关,差异有统计学意义(P<0.05),HA、Ⅳ-C、APRI以及Fib-4的曲线下面积(AUC)分别为0.646、0.695、0.743、0.701。结论 4个血清学指标和乙型肝炎后纤维化具有很好的相关性,对临床进行无创肝纤维化诊断具有一定的价值。Objective To evaluate the diagnosis efficiency of hyaluronic acid(HA) and Ⅳ-collagen(Ⅳ-C)in patients with liver fibrosis after hepatitis B. Aspartate aminotransferase(AST)/platelet(PLT) ratio(APRI) and fibrosis 4 score(Fib-4)for liver fibrosis after hepatitis B. Methods A total of 320 patients with hepatitis B were enrolled. Their general data,like age and sex,were recorded. The patients were classified according to the Metavir scoring system. The HA and Ⅳ-C levels were detected by chemiluminescence,and APRI and Fib-4 were calculated. Their roles have been evaluated according to receiver operating characteristic(ROC)curve analysis. Results HA,Ⅳ-C,APRI and Fib-4 were positively correlated with the stage of liver fibrosis with statistical significance(P<0.05),and the areas under curves(AUC) of HA,Ⅳ-C,APRI and Fib-4 were 0.646,0.695,0.743 and 0.701,respectively. Conclusions HA,Ⅳ-C,APRI and Fib-4 have correlations with hepatitis B-related liver fibrosis. They are potential in the non-invasive diagnosis of hepatitis B-related liver fibrosis.

关 键 词：透明质酸 Ⅳ型胶原 天门冬氨酸氨基转移酶/血小板比值 纤维蛋白原 慢性乙型肝炎 肝纤维化 

分 类 号：R446.1[医药卫生—诊断学]