Menin:一个新的神经系统疾病防治靶点  

Menin: a novel therapeutic target for neurological diseases

作　　者：朱慰文 杨三桥 唐小卿 ZHU Wei-wen;YANG San-qiao;TANG Xiao-qing(Institute of Neuroscience & Department of Physiology,Hengyang Medical College,University of South China,Hengyang Hunan 421001)

机构地区：[1]南华大学衡阳医学院神经科学研究所生理学教研室

出　　处：《中南药学》2019年第6期889-894,共6页Central South Pharmacy

基　　金：国家自然科学基金(No.81671057,No.81771178);2018年湖南省研究生科研创新项目(No.CX2018B619);2018年南华大学研究生科学基金项目(No.2018KYZ048)

摘　　要：Menin蛋白是MEN1基因编码的产物,可通过调控突触可塑性和神经炎症发挥神经保护作用。神经炎症的发生和突触可塑性障碍被证明参与大多数神经系统疾病的发病过程,因此开发抑制神经炎症和改善突触可塑性的药物对治疗神经系统疾病具有重要意义。所以本文将综述Menin在神经系统疾病相关症状中的调节作用及潜在机制,并展望Menin对阿尔兹海默症和帕金森病等神经退行性疾病的潜在防治作用。Menin protein, the product of MEN1 gene encoding, plays a neuroprotective role by regulating the synaptic plasticity and neuroinflammation. Neuroinflammation and synaptic plasticity disorder have been proved to be involved in the pathogenesis of most neurological diseases. Therefore, the development of drugs to inhibit the neuroinflammation and improve synaptic plasticity is of great significance in the treatment of neurological diseases. This paper reviewed the Menin’s protective effect on and potential mechanism for neurological disease related symptoms, and looked into Menin’s potential prevention and treatment effect on Alzheimer’s disease, Parkinson’s disease and other neurodegenerative diseases.

关 键 词：MENIN蛋白 神经系统疾病 神经炎症 突触可塑性 

分 类 号：R96[医药卫生—药理学]