血管衰老中的表观遗传调控  

Epigenetic regulation in vascular aging

作　　者：丁杨楠 吕双杰 陈厚早[1] 刘德培[1] DING Yangnan;Lü Shuangjie;CHEN Houzao;LIU Depei(State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100005,China)

机构地区：[1]中国医学科学院北京协和医学院基础医学研究所医学分子生物学国家重点实验室

出　　处：《上海大学学报（自然科学版）》2019年第3期381-388,共8页Journal of Shanghai University:Natural Science Edition

基　　金：中国医学科学院医学表观遗传研究中心资助项目(2017PT31035,2018PT31015)

摘　　要：血管衰老是伴随年龄增长而出现的血管结构和功能的改变,主要包括血管重塑、血管稳态失衡以及血管细胞的衰老.表观遗传调控是在不改变 DNA 序列的情况下改变基因的表达,其主要机制包括 DNA 甲基化、组蛋白修饰以及非编码 RNA 的调控等.目前的研究表明各种表观遗传调控途径参与血管衰老的各个层面,在血管衰老及相关疾病的发生发展中扮演重要角色.靶向表观遗传调控的药物有望成为衰老相关疾病新的治疗方向.Vascular aging refers to the structural and functional changes of aorta during the aging process. It is characterized by vascular remodeling, vascular dyshomeostasis and vascular cell senescence. Epigenetic regulation can influence gene expression without changing the DNA sequence and it mainly includes DNA methylation, histone modifications, and RNA-based gene regulation. Current researches demonstrate that epigenetic regulation plays important roles in vascular aging and age-related diseases, and drugs targeting epigenetic regulation are expected to be new treatments for age-related diseases.

关 键 词：血管衰老 表观遗传调控 DNA甲基化 组蛋白修饰 非编码RNA Senescaging 

分 类 号：R34[医药卫生—基础医学]