糖代谢异常对中老年人高尿酸血症和腹部脂肪容积及分布的影响  

Relationship between hyperuricemia and abdominal fat in middle-aged and elderly people with glucose metabolism disorder

作　　者：倪雪峰 牟文斌[2] 焦力 于康 李冬晶 Ni Xuefeng;Mou Wenbin;Jiao Li;Yu Kang;Li Dongjing(Department of Health Care,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院保健医疗部,北京100730 [2]中国医学科学院北京协和医学院北京协和医院放射科,北京100730

出　　处：《中国临床保健杂志》2019年第4期451-454,共4页Chinese Journal of Clinical Healthcare

基　　金：中央保健重点科研课题(W2015ZD03)

摘　　要：目的 分析糖代谢异常对中老年人高尿酸血症、腹部脂肪容积及分布的影响。方法 根据北京协和医院保健医疗部2015—2018年间183例年龄50岁以上体检者的腹部CT,计算其腹部脂肪容积与分布,分析高尿酸血症、糖代谢异常的资料分布。结果 高尿酸血症人群的体质量[(73.9±13.0)kg]比正常尿酸人群[(69.4±10.2)kg]明显增加(P<0.05),腰围明显较大[(91.7±7.9)cm比(88.8±7.6)cm,P<0.05],腹部内脏脂肪容积明显增多[(75.0±30.2)cm3比(63.9±28.6)cm3,P<0.05]。糖代谢正常人群中,有无高尿酸血症,其体质量、体质指数、腰围、腹部内脏脂肪容积、腹部皮下脂肪容积、腹部脂肪总容积、腹部内脏脂肪百分比均差异无统计学意义;糖代谢异常人群中,高尿酸血症的人群较正常尿酸人群腹部内脏脂肪容积明显较多[(80.7±30.9)cm3比(65.2±27.5)cm3,P<0.05],腹部脂肪总量明显增多[(169.2±57.8)cm3比(144.7±53.4)cm3,P<0.05]。结论 在50岁以上有糖代谢异常的人群,如有高尿酸血症往往腹部内脏脂肪容积将明显增多。50岁以上糖代谢正常的人群,高尿酸血症与腹部内脏脂肪容积之间没有相关性。Objective To analyze the effects of abnormal glucose metabolism on hyperuricemia, abdominal fat volume and distribution in middle-aged and elderly people. Methods According to the abdominal CT scan in 2015-2018 for 183 patients in Peking Union Medical College Hospital,we measured the abdominal fat,and analyzed the difference of fat volume and distribution based on hyperuricemia and glucose metabolic disorder. Results Hyperuricemia people had significantly higher body weight [(73.9±13.0)kg vs (69.4±10.2)kg, P <0.05)],significantly larger waist circumference [(91.7±7.9)cm vs (88.8±7.6)cm, P <0.05],significantly higher abdominal visceral fat volume [(75.0±30.2)cm 3 vs (63.9±28.6)cm 3, P <0.05].For people without glucose metabolic disorder,there were no significant changes in body weight,body mass index,waist circumference,abdominal visceral fat volume,abdominal subcutaneous fat volume,total abdominal fat volume and percentage of abdominal visceral fat,with or without hyperuricemia.For people with glucose metabolic disorder,hyperuricemia people had significantly larger abdominal visceral fat volume [(80.7±30.9)cm 3 vs (65.2±27.5)cm 3, P <0.05] and total visceral fat volume [(169.2±57.8)cm 3 vs (144.7±53.4)cm 3 , P <0.05]. Conclusions For people over 50 years of age with glucose metabolism disorder,the volume of abdominal visceral fat in patients with hyperuricemia or gout increase significantly.There is no correlation between hypercapnia or gout and abdominal visceral fat volume in people over 50 years old without glucose metabolism disorder.

关 键 词：高尿酸血症 腹部脂肪 葡萄糖代谢障碍 腹内脂肪 肥胖 腹部 

分 类 号：R587.1[医药卫生—内分泌] R589.7[医药卫生—内科学]