福建地区5家部队医院23551例药品不良反应报告  

Reports of 23 551 Adverse Drug Reactions in 5 Military Hospitals in Fujian

作　　者：李扬 庄佳芳 史涛[1] 朱建明 LI Yang;ZHUANG Jiafang;SHI Tao;ZHU Jianming(Dept.of Pharmacy,the 174th Hospital of the PLA (Army 73rd Group Army Hospital),Fujian Xiamen 361001,China;Drug and Equipment Section,PLA Army Xiamen Special Service Nursing Center,Fujian Xiamen 361001,China)

机构地区：[1]解放军第一七四医院(陆军第七十三集团军医院)药剂科,福建厦门361001 [2]解放军陆军厦门特勤疗养中心药械科,福建厦门361001

出　　处：《中国医院用药评价与分析》2019年第5期625-627,630,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨福建地区部队医院药品不良反应(adverse drug reaction,ADR)的分布特点,为临床合理用药提供参考。方法:汇总2014—2018年福建地区5家部队医院的ADR报告23 551例,对ADR报告类型、患者的基本信息、药品信息、给药途径、ADR累及器官和(或)系统及临床表现等进行统计分析。结果:23 551例ADR报告中,一般的ADR较多(16 868例,占71.62%);男性(11 802例)与女性(11 749例)患者数相当;>50岁者多见(14 809例,占62.88%)。ADR涉及药物类别以抗感染药、抗肿瘤药和中成药为主,共12 139例(占51.54%);抗感染药中,头孢菌素类、氟喹诺酮类抗菌药物所致ADR病例数最多。引发ADR的给药途径以静脉给药为主(16 441例,占69.81%),药品剂型主要为注射剂(18 061例,占76.69%)。ADR主要累及胃肠道、皮肤及其附件,共16 183例次(占总例次数32 971例次的49.08%)。95.92%(22 590例)的ADR转归情况为痊愈或好转。结论:ADR的发生与多种因素有关,医务人员应加强监护,采取合理的措施,促进临床合理用药。OBJECTIVE:To explore the distribution characteristics of adverse drug reactions (ADR) in military hospitals in Fujian,so as to provide reference for the rational drug use in clinic.METHODS:Totally 23 551 ADR reports in 5 military hospitals in Fujian from 2014 to 2018 were summarized,and statistical analysis was conducted on types of ADR reports,patients’ basic information,drug information,route of administration,ADR involved organs and(or) systems and clinical manifestations.RESULTS:Of the 23 551 ADR reports,there were more general ADR (16 868 cases,71.62%);the number of males (11 802) was comparable to that of females (11 749);patients aged > 50 years old (14 809 cases,62.88%) took the lead.Drugs involved in ADR were mainly anti-infective drugs,anti-tumor drugs and Chinese patent drugs,with a total of 12 139 cases (51.54%).Among the anti-infective drugs,the number of ADR cases caused by cephalosporins and fluoroquinolones were the most.The route of administration of ADR was mainly intravenous (16 441 cases,69.81%),and the drug dosage form was mainly injection (18 061 cases,76.69%).ADR mainly involved gastrointestinal tract,skin and its accessories,with a total of 16 183 case-times (49.08% of the total 32 971 case-times).And 95.92%(22 590 cases) of ADR outcomes were cured or improved.CONCLUSIONS:The occurrence of ADR is related to a variety of factors.Medical staff should strengthen the supervision and take reasonable measures to promote the clinical rational use of drugs.

关 键 词：药品不良反应 合理用药 分析 

分 类 号：R969.3[医药卫生—药理学] R97[医药卫生—药学]