三七总皂苷对杠柳毒苷代谢产物杠柳次苷药代动力学的影响  

Effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin

作　　者：李丽[1] 贾琪[1] 姚广哲 欧阳慧子[2] 常艳旭[1] 何俊[1] LI Li;JIA Qi;YAO Guangzhe;OUYANG Huizi;CHANG Yanxu;HE Jun(Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学,天津市现代中药重点实验室,天津301617 [2]天津中医药大学第一附属医院,天津300193

出　　处：《天津中医药》2019年第6期608-611,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81673824,81503457)

摘　　要：[目的]研究三七总皂苷对杠柳毒苷代谢产物杠柳次苷药代动力学的影响。[方法]将18只SD大鼠随机分为杠柳毒苷单独给药组、杠柳毒苷与低剂量三七总皂苷配伍组、杠柳毒苷与高剂量三七总皂苷配伍组3组,每组6只。各组大鼠连续灌胃给药7 d后,采集不同时间点的血浆样品,测定血浆中杠柳次苷的含量,并计算其药代动力学参数。[结果]三七总皂苷配伍杠柳毒苷后,杠柳毒苷代谢产物杠柳次苷在大鼠血浆中的主要药动学参数Cmax、Tmax、AUC0-t、AUC0-∞与杠柳毒苷单独给药相比具有统计学差异。[结论]三七总皂苷与杠柳毒苷配伍使用可使杠柳毒苷代谢产物杠柳次苷的药代动力学行为发生改变。[Objective] To study the effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin in rats.[Methods] Eighteen rats were divided into periplocin alone group;periplocin combined with low-and high-dose Panax notoginsenosides groups. All rats were orally administered for seven consecutive days,blood samples were obtained from orbitalis at different time before and after the last time administration. After that,the concentration of periplocymarin in plasma was determined,and main pharmacokinetic parameters of analyte were processed.[Results] Results of pharmacokinetics showed that there were significant differences between the pharmacokinetic parameters of periplocin metabolite of periplocymarin in rats as Cmax,Tmax,AUC0-tand AUC0-∞with or without Panax notoginsenosides.[Conclusion] The compatibility of Periplocin and Panax notoginsenosides can change the pharmacokinetic behavior of periplocin metabolite of periplocymarin.

关 键 词：杠柳次苷 三七总皂苷 液相色谱-质谱联用 药代动力学 

分 类 号：R285.5[医药卫生—中药学]