等离子激元单颗粒纳米生物探针界面调控与应用  

Surface Regulation of Single Plasmonic Nanoparticle and its Application in Biological Nanoprobe

作　　者：沈晶晶[1] 张磊[1] SHEN Jing-jing;ZHANG Lei(Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials,,Nanjing Jiangsu 210023,China)

机构地区：[1]南京邮电大学信息材料与纳米技术研究院有机电子与信息显示国家重点实验室培育基地

出　　处：《科技视界》2019年第14期1-2,56,共3页Science & Technology Vision

基　　金：南京邮电大学校级科研基金资助“基于纳米Au@Ag立方体的单颗粒等离子激元生物传感研究”(NY215173)

摘　　要：本研究主要利用不同形貌、尺寸的单个等离子激元纳米颗粒为基底,实现了高灵敏的生物传感,检测灵敏度达到单分子水平;结合DNA特异杂交与折纸技术,实现生物分子在等离子激元界面状态的精确调控,并对其形态转变的动力学过程进行观测。经过多年的研究,我们在单颗粒水平上构建了一系列基于等离子激元的高灵敏高选择性纳米生物传感器,这些创新成果推动了纳米生物传感分析化学的发展。In this study,single plasmon nanoparticles with different morphologies and sizes were used as the substrate to achieve highly sensitive biological sensing,and the detection sensitivity reached the single-molecule level.Combining DNA specific hybridization and origami technology,the precise regulation of biomolecules in plasmon interface state was realized,and the kinetic process of morphological transformation was observed.After years of research,we have constructed a series of highly sensitive and highly selective nanobiosensors based on plasmons at the single-particle level.These innovative achievements have promoted the development of nanobiosensor analytical chemistry.

关 键 词：等离子激元 生物探针 单颗粒 界面调控 

分 类 号：TB383.1[一般工业技术—材料科学与工程]