中性粒细胞及血小板与淋巴细胞比值与2型糖尿病视网膜病变相关性  

Correlation of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

作　　者：吴佩佩 鲁晓 吴清静[1] 刘彩霞[1] 陈云飞[1] 谢青[1] Pei-Pei Wu;Xiao Lu;Qing-Jing Wu;Cai-Xia Liu;Yun-Fei Chen;Qing Xie(Central South University Xiangya School of Medicine Affiliated Haikou Hospital,Haikou 570100,Hainan Province,China;Department of Ophthalmology,the First People s Hospital of Huaihua,Huaihua 418000,Hunan Province,China)

机构地区：[1]中国海南省海口市中南大学湘雅医学院附属海口医院海南省海口市人民医院眼科,570100 [2]中国湖南省怀化市第一人民医院眼科,418000

出　　处：《国际眼科杂志》2019年第7期1101-1105,共5页International Eye Science

基　　金：海南省自然科学基金项目(No.814370);海南省医药卫生科研项目(No.1601032037A2003)~~

摘　　要：目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。方法:选择2型糖尿病(DM)患者200例,按眼底检查结果分为眼底正常组( n =100)、非增殖期视网膜病变组(NPDR, n =62)和增殖期视网膜病变组(PDR, n =38)。同时选取100例健康体检者作为正常对照( n =100)组;测定中性粒细胞、淋巴细胞及血小板计数等相关指标。结果: PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85),差异有统计学意义( P <0.05),PDR组患者PLR值(126.18)高于DM组(111.64),差异有统计学意义( P <0.05)。Logistic回归分析显示,年龄(β=-0.047)是糖尿病视网膜病变的保护因素( P <0.05),病程(β=0.071)和收缩压(β=0.024)是危险因素( P <0.05),而NLR、PLR在回归分析中无统计学意义。结论:NLR、PLR值在PDR组升高,但并非糖尿病视网膜病变发生的独立危险因素。AIM: To investigate the relationship between neutrophil- to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and type 2 diabetic retinopathy (DR). METHODS:A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus (DM, n =100), non-proliferative diabetic retinopathy (NPDR, n =62) and proliferative diabetic retinopathy (PDR, n =38). 100 healthy persons were selected as the normal control group (NCG, n =100). The related indicators, such as neutrophil count, lymphocyte count and platelet count were measured. RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group (1.81), DM group (1.76) and NPDR group (1.85)( P <0.05). The value of PLR was significantly higher in PDR group patients (126.18) than in DM group (111.64)( P <0.05). Logistic regression analysis showed that age (β=-0.047) was protective factor, course of diabetes (β=0.071) and systolic blood pressure (β=0.024) were risk factors for diabetic retinopathy ( P <0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis. CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.

关 键 词：2型糖尿病 糖尿病视网膜病变 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 

分 类 号：R587.2[医药卫生—内分泌]