杭州市大气污染对学龄儿童肺功能的短期效应研究  

Short-term effects of air pollution on lung function of school-age children in Hangzhou

作　　者：刘卫艳[1] 张磊[2] 徐虹[1] 徐珊珊[1] 吕烨[1] 张文辉[1] 章美 王峥[4] 陈树昶[5] 叶春[6] 叶辉[7] 温圆圆[8] Liu Weiyan;Zhang Lei;Xu Hong;Xu Shanshan;LV Ye;Zhang Wenhui;Zhang Mei;Wang Zheng;Chen Shuchang;Ye Chun;Ye Hui;Wen Yuanyuan(Department of Environmental Health, Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, China;Office, Hangzhou Hospital for the Prevention and Treatment of Occupational Disease, Hangzhou 310021, China;Department of Surveillance, Chun'an Center for Disease Control and Prevention, Hangzhou 310021, China;Department of Surveillance, Xiacheng Center for Disease Control and Prevention, Hangzhou 310006, China;Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, China;Department of Information Center, Hangzhou Meteorological Administration, Hangzhou 310021, China;Department of autocontrol, Hangzhou Environmental Monitoring, Hangzhou 310021, China;Department of Infectious Diseases Control, Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, China)

机构地区：[1]杭州市疾病预防控制中心环境卫生所,310021 [2]杭州市职业病防治院办公室,310021 [3]杭州市淳安县疾病预防控制中心卫生监测科,310021 [4]杭州市下城区疾病预防控制中心监测科,310021 [5]杭州市疾病预防控制中心,310021 [6]杭州市气象局信息中心,310021 [7]杭州市环境监测中心站自动室,310021 [8]杭州市疾病预防控制中心传染病防制所,310021

出　　处：《中华预防医学杂志》2019年第6期614-618,共5页Chinese Journal of Preventive Medicine

基　　金：浙江省医药卫生科技计划(2015KYB317);杭州市科技发展计划(20140533B15);杭州市社会发展科研自主申报项目(20180533B92);杭州市科技计划引导项目(20163501Y37).

摘　　要：为分析杭州市大气污染对学龄儿童肺功能的短期影响,选择1 685名小学生进行肺功能检测,测量当天和前1天的PM2.5和PM10平均浓度每升高10μg/m^3,呼气流量峰速(PEF)分别降低0.039(95%CI:0.012~0.067)和0.031(95%CI:0.011~0.051)L/s;测量当天和前1天的SO2平均浓度每升高10μg/m3,PEF和75%最大呼气流速(MEF75)分别降低0.437(95%CI:0.217~0.658)和0.396(95%CI:0.180~0.613)L/s。调整NO2后,测量当天和前1天的PM2.5和PM10平均浓度每升高10μg/m^3时,PEF分别降低0.056(95%CI:0.028~0.085)和0.047(95%CI:0.026~0.068)L/s,MEF75分别降低0.053(95%CI:0.027~0.081)和0.044(95%CI:0.023~0.065)L/s。杭州市大气污染物对学龄儿童肺功能存在短期滞后效应。A total of 1 685 school-age children selected from Hangzhou received lung function testing to evaluate the short-term effects of air pollution on their lung function.The results showed that in every 10μg/m^3 increase of average concentration of PM2.5 and PM10 on the day of the test and the day before the test,peak expiratory flow(PEF)decreased 0.039(95%CI:0.012-0.067)L/s and 0.031(95%CI:0.011-0.051)L/s,respectively.When the average concentration of SO2 increased 10μg/m^3 on the day of test and the day prior to the test,PEF and 75%of the forced vital capacity that has not been exhaled(MEF75)decreased 0.437(95%CI:0.217-0.658)L/s and 0.396(95%CI:0.180-0.613)L/s.After being adjusted for NO2,with every 10μg/m3 increase of average concentration of PM2.5 and PM10 on the day of the test and the day before the test,PEF and MEF75 decreased 0.056(95%CI:0.028-0.085),0.053(95%CI:0.027-0.081)and 0.047(95%CI:0.026-0.068)L/s,0.044(95%CI:0.023-0.065)L/s on the day before the test,respectively.The results indicate that air pollution have short-term and lag effects on lung function of school-age children in Hangzhou.

关 键 词：空气污染物 呼吸功能试验 儿童 混合效应模型 

分 类 号：X51[环境科学与工程—环境工程] R725.6[医药卫生—儿科]