双功能乙醛/乙醇脱氢酶AdhE参与细菌与宿主互作的机制研究进展  

Regulatory mechanisms of aldehyde/alcohol dehydrogenase in bacteria-host interactions

作　　者：蔡瑶 龚双燕 陈瑛琪 李幽幽 李小璟 徐志文 朱玲 CAI Yao;GONG Shuang-Yan;CHEN Ying-Qi;LI You-You;LI Xiao-Jing;XU Zhi-Wen;ZHU Ling(Key Laboratory of Animal Disease and Human Health of Sichuan Province,Animal Biotechnology Center,College ofVeterinary Medicine of Sichuan Agricultural University,Chengdu,Sichuan 611130,China)

机构地区：[1]四川农业大学动物医学院动物生物技术中心动物疫病与人类健康四川省重点实验室

出　　处：《微生物学通报》2019年第6期1530-1536,共7页Microbiology China

基　　金：四川省科技支撑计划(2017NZ0038);十二五农村领域国家科技计划课题(2015BAD12B04-2.3);十三五育种攻关计划(2016NYZ0052);国家农业产业技术体系四川兽药创新团队专项(CARS-SVDIP)~~

摘　　要：双功能乙醛/乙醇脱氢酶AdhE具有乙醛脱氢酶和乙醇脱氢酶的催化活性,是细菌乙醇厌氧发酵途径中的关键酶之一。近年,有关细菌与宿主相互作用的研究表明,AdhE在细菌适应宿主内环境变化和发挥毒力时具有重要的调控作用。本文对AdhE参与调控细菌感染宿主的致病机制和参与细菌对宿主免疫功能调节的作用机制进行综述,以期为AdhE的功能研究提供新的思路。The bifunctional aldehyde/ethanol dehydrogenase(AdhE) exhibits acetaldehyde dehydrogenase(ALDH) and alcohol dehydrogenase(ADH) activities, and is one of the key enzymes in the bacterial ethanol anaerobic fermentation pathway. Researches on bacteria-host interactions revealed that AdhE also plays an important role in bacteria adapting to the internal environment changes and regulating bacterial virulence. In this paper, we summarized the regulatory mechanisms of AdhE on bacterial pathogenesis and host immune,which may provide new perspectives for understanding AdhE’s function.

关 键 词：乙醛/乙醇脱氢酶 细菌-宿主互作 致病机制 

分 类 号：Q939.91[生物学—微生物学]