膝骨关节炎患者血清GPI、抗MCV抗体水平变化及其意义  

Changes in levels of serum GPI and anti-MCV antibody in patients with knee osteoarthritis

作　　者：刘轩[1] 徐翔 王静[1] 赵静[1] 李鸿斌[1] LIU Xuan;XU Xiang;WANG Jing;ZHAO Jing;LI Hongbin(The Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, China)

机构地区：[1]内蒙古医科大学附属医院,呼和浩特010050 [2]内蒙古医科大学第二附属医院

出　　处：《山东医药》2019年第15期33-36,共4页Shandong Medical Journal

基　　金：内蒙古医科大学实验室开放基金(2018ZN14)

摘　　要：目的 观察膝骨性关节炎(KOA)患者血清葡萄糖-6-磷酸异构酶(GPI)、抗突变型瓜氨酸波形蛋白(MCV)抗体水平变化,并探讨其意义。方法 100例KOA患者按照病情进展分为早期组、中晚期组各50例,另选50例健康体检者作为对照组,比较各组GPI、抗MCV抗体、血沉(ESR)、C反应蛋白(CRP)水平,并分析各指标的相关性。结果 早期组血清GPI、抗MCV抗体、ESR、CRP水平分别为(0.038±0.110)mg/L、(11.40±15.05)U/mL、(19.08±20.70)mm/h、(10.10±23.60)mg/L;中晚期组分别为(0.098±0.560)mg/L、(7.13±8.67)U/mL、(21.30±21.87)mm/h、(24.35±34.90)mg/L;对照组分别为(0.010±0.050)mg/L、(4.80±2.87)U/mL、(10.77±5.65)mm/h、(1.17±1.03)mg/L;早期组、中晚期组各指标分别与对照组比较,早期组CRP水平与中晚期组比较,P均<0.05。KOA患者血清GPI水平与CRP水平呈正相关(r=0.27,P<0.05),与ESR水平无相关性(r=0.06,P>0.05);抗MCV抗体水平与CRP、ESR水平无相关性(r=0.03、0.14,P均>0.05)。结论 KOA患者血清中GPI、抗MCV抗体水平升高,检测两指标有助于KOA的诊断及病情评估。Objective To observe the changes of glucose -6-phosphate isomerase (GPI) and anti-mutated citrullinated vimentin (MCV) antibody in serum of patients with knee osteoarthritis (KOA) and to explore its significance. Methods According to the disease progression, 100 patients with KOA were divided into the early stage group and the middle and late stage group with 50 cases in each, and the healthy examiners were selected as the control group. The levels of GPI, anti-MCV antibody, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in each group were compared, and the correlation of each index was analyzed. Results The levels of GPI, anti-MCV antibody, ESR, and CRP levels in serum were (0.038±0.11) mg/L,(11.4±15.05) U/mL,(19.08±20.7) mm/h,(10.1±23.6) mg/l, respectively in the early group,(0.098 ±0.56) mg/L,(7.13±8.67) U/mL,(21.3±21.87) mm/h, and (24.35±34.9) mg/L, respectively, in the middle and late group, and (0.01±0.05) mg/L,(4.8±2.87) U/mL,(10.77±5.65) mm/h, and (1.17±1.03) mg/L, respectively, in the control group. Significant difference was found in each index between the early stage group and middle and late stage group, as well as in the CRP level between the early stage group and the middle and late stage group (all P <0.05). The serum GPI level was positively correlated with CRP level in KOA patients ( r =0.27, P <0.05), but was not with ESR level ( r =0.06, P >0.05). There was no correlation between anti-MCV antibody level and CRP and ESR levels (r=0.03 and 0.14, all P >0.05)Conclusion The levels of GPI and anti-MCV antibody in serum of KOA patients increase, and the detection of two indexes is helpful to the diagnosis and evaluation of KOA.

关 键 词：膝骨关节炎 葡萄糖-6-磷酸异构酶 抗突变型瓜氨酸波形蛋白抗体 血沉 C反应蛋白 

分 类 号：R446.62[医药卫生—诊断学]