NLRP3炎性体在心肌病和心律失常中的作用及研究进展  

Role and research progress of NLRP3 inflammasome in cardiomyopathy and arrhythmias

作　　者：李威 刘明鑫[1] 唐艳红[1] LI Wei;LIU Ming-xin;TANG Yan-hong(Department of Cardiology,Renmin Hospital of wuhan University,Cardiovascular Research Institute ofwuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院心内科武汉大学心血管病研究所心血管病湖北省重点实验室

出　　处：《心脏杂志》2019年第3期334-338,共5页Chinese Heart Journal

摘　　要：NLRP3炎性体是先天免疫反应的参与者,通过相关激活信号来触发炎症。NLRP3炎性体在心肌细胞和心脏成纤维细胞中表达,通过水解含半胱氨酸的天冬氨酸蛋白水解酶(caspase-1)前体生成caspase-1促使白介素(IL)-1β、IL-18的成熟和释放而导致细胞焦亡,其浸润影响到心肌病和心律失常等心血管疾病的发生发展过程。在这篇综述中,我们介绍了NLRP3炎性体在心肌病和心律失常中的作用及相关机制,对探索针对NLRP3炎症体在此类疾病中的治疗方案有重要意义。NLRP3 inflammasome is a participant in the innate immune response that triggers inflammation through a related activation signal.NLRP3 inflammasome is expressed in cardiomyocytes and cardiac fibroblasts,and caspase-1 is generated by procaspase-1 hydrolyzed to promote the maturation and release of IL-1βand IL-18,resulting in cell pyroptosis.Its infiltration affects the development of cardiovascular diseases such as cardiomyopathy and arrhythmia.In this review,we describe the role and related mechanisms of NLRP3 inflammasomes in cardiomyopathy and arrhythmias,which are important in exploring treatment options for NLRP3 inflammasome related diseases.

关 键 词：NLRP3炎性体 心肌病 心律失常 焦亡 纤维化 

分 类 号：R541.7[医药卫生—心血管疾病]