动态表面张力在药剂学研究中的应用前景  

Application prospect of dynamic surface tension in pharmaceutical research

作　　者：施晓虹 李佳璇 洪燕龙 赵立杰[1] 冯怡[1] 王优杰[1] SHI Xiao-hong;LI Jia-xuan;HONG Yan-long;ZHAO Li-jie;FENG Yi;WANG You-jie(Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education,Innovation Research Institute of Traditional Chinese Medicine;Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

机构地区：[1]上海中医药大学创新中药研究院中药现代制剂技术教育部工程研究中心,上海201203 [2]上海中医药大学上海中医健康服务协同创新中心,上海201203

出　　处：《国际药学研究杂志》2019年第1期27-34,共8页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81503263);上海市科学技术委员会资助项目(16401902300);上海市卫计委中医药科技创新项目(ZYKC201603003)

摘　　要：动态表面张力(DST)是体现液体表面张力变化的一个物理量,是评价液体运动特性的关键物理属性之一,目前在工业、农业等领域已受到广泛关注。本文从动态表面吸附、DST测定方法等方面详细介绍了DST;以表面活性剂溶液的DST为切入点,从液体的雾化、扩散润湿、表界面特性等角度讨论了液体DST对改善药物喷雾干燥过程的影响,及其对流化床制粒包衣效果的作用;通过分析固体物料遇水瞬间的行为,探讨了辅料增溶效果、片剂崩解机制等;旨在通过总结归纳国内外DST研究成果,阐述DST在药剂学研究中的应用价值。Dynamic surface tension(DST)is a key physical property that reflects the variable surface tension and the movement characterization of liquid. It is widely used in industry,agriculture and other fields. This paper aims to summarize the recent advances in the DST studies and to explore the application value of DST in pharmaceutical researches. The paper introduces DST focusing on the process of dynamic surface adsorption and the methods of DST measurement. Furthermore,focusing on the DST in surfactant solutions,the effect of DST in the improvement of drying,granulating and coating processes of drugs by the spray drying or fluidized bed method are discussed in a combined consideration of the atomization,diffusion and wetting of liquid as well as the surface interface characteristics,etc. Moreover,by analyzing the instantaneous behavior of solid materials in contact with water,the solubilizing effect of excipients and the disintegrating mechanism of tablets are discussed.

关 键 词：动态表面张力 动态吸附 表面活性剂 药物制剂 

分 类 号：R943.4[医药卫生—药剂学]