比阿培南治疗慢性肝病合并急性细菌性感染820例有效性和安全性多中心回顾性研究  

Safety and Efficacy of Biapenem in the Treatment of 820 Cases of Chronic Liver Disease Complicated with Acute Bacterial Infection:A Retrospective Multicenter Open-label Cohort Study

作　　者：吴亮[1] 唐世刚[2] 阚晓[3] 朱传武[4] 邱源旺 李粤平 徐天敏[7] 黄建荣 田德英 WU Liang;TANG Shigang;KAN Xiao;ZHU Chuanwu;QIU Yuanwang;LI Yueping;XU Tianmin;HUANG Jianrong;TIAN Deying(Department of Infectious Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Infectious Diseases,Hunan Provincial People's Hospital,Changsha 410645,China;Department of Hepatology,Jinan Infectious Disease Hospital,Jinan 251621,China;Department of Infectious Diseases,The Fifth People's Hospital of Suzhou,Suzhou 215639,China;Department of Infectious Diseases,the Fifth People's Hospital of Wuxi,Wuxi 214443,China;Department of Hepatology,the Eighth People's Hospital of Guangzhou,Guangzhou 511480,China;Department of Infectious Diseases,the Third People's Hospital of Changzhou,Changzhou 213263,China;Department of Infectious Diseases,The First Affiliated Hospital of Zhejiang University,Hangzhou 311713,China)

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,武汉430030 [2]湖南省人民医院感染科,长沙410645 [3]济南市传染病医院肝病科,济南251621 [4]苏州市第五人民医院感染科,苏州215639 [5]无锡市第五人民医院感染科,无锡214443 [6]广州市第八人民医院肝病科,广州511480 [7]常州市第三人民医院感染科,常州213263 [8]浙江大学附属第一医院感染科,杭州311713

出　　处：《医药导报》2019年第7期906-910,共5页Herald of Medicine

摘　　要：目的评价比阿培南治疗慢性肝病合并急性细菌性感染的有效性和安全性。方法采用多中心回顾性研究,820例慢性肝病合并急性细菌性感染患者,给予阿培南300mg+0.9%氯化钠注射液100mL静脉滴注,滴注时间30~180min,q8h或q6h,治疗时间≥3d,比阿培南一般疗程7~14d。结果比阿培南有效率75.73%。痊愈率、显效率、进步率、无效率及死亡率分别为22.45%,41.95%,23.22%,10.37%和2.01%。细菌清除率和假定清除率分别为42.86%和47.96%。药物不良反应发生率1.10%。结论比阿培南治疗慢性肝病合并急性细菌性感染安全、有效。Objective To evaluate the efficacy and safety of biapenem in the treatment of chronic liver disease complicated with acute bacterial infection. Methods A retrospective multicenter open-label cohort study was conducted in 820 patients.Each patient was given biapenem 300 mg,q6 h or q8 h. The treatment period of biapenem was generally 7-14 days.Results The effective rate were 75.73%.The cure rate,markedly effective rate,progressive rate,inefficiency and mortality rate were 22.45%,41.95%,23.22%,10.37% and 2.01%,respectively. The bacterial clearance rate and presumed clearance rate were 42.86% and 47. 96%,respectively. Adverse drug reaction rate was 1. 10%. Conclusion Biapenem in the treatment of chronic liver disease with acute bacterial infection is safe and effective.

关 键 词：比阿培南 肝病 慢性 感染 细菌性 安全性 有效性 回顾性研究 

分 类 号：R978.1[医药卫生—药品] R511[医药卫生—药学]