覆膜镍钛合金支架管与改良型结肠液囊管在猪结肠穿孔修复中的应用对比观察  

Comparison inapplication of LF-NTST and MCST in colorectal perforationhealingof Tibet miniature pigs

作　　者：王纯忠[1] 卢峰 仇卫健 高小龙 肖慧莲[1] 谢明霞 杨茂华[1] 区栋财 刘楚天 WANG Chunzhong;LU Feng;QIU Weijian;GAO Xiaolong;XIAO Huilian;XIE Mingxia;YANG Chenghua;QU Dongcai;LIU Chutian(Guangzhou First People′s Hospital,Guangzhou 510380,China)

机构地区：[1]广州市第一人民医院,广州510380 [2]江苏阳普医疗科技有限公司 [3]南京微创科技有限公司

出　　处：《山东医药》2019年第18期52-55,共4页Shandong Medical Journal

摘　　要：目的观察覆膜镍钛合金支架管(Laminated film nickel-titanium alloy stent tube, LF-NTST )、改良型结肠液囊管(modified colon sac tube, MCST)对结肠穿孔猪穿孔部位的应用修复效果。方法 取48头西藏小型猪制备结肠穿孔模型,造模后48只猪随机分为LF-NTST组、MCST组,每组24头。造模后即刻LF-NTST组、MCST组分别用LF-NTST与MCST修复结肠穿孔部位。分别于治疗第7、14、21天两组各取8只猪测算结肠穿孔愈合部位爆破压(BP),取结肠穿孔部位肠壁组织检测直肠穿孔愈合部位羟脯氨酸(HC)含量。结果 治疗第7、14、21天LF-NTST组结肠穿孔愈合部位BP分别为(27.21±0.98)、(35.77±0.72)、(38.13±0.92)Kpa,MCST组分别为(26.83± 0.91 )、(35.23±0.55)、(37.20±0.95)Kpa。随治疗时间延长LF-NTST组、MCST组结肠穿孔愈合部位BP逐渐升高( P 均<0.05)。治疗第7、14、21天LF-NTST组结肠穿孔愈合部位HC含量分别为(22.40±0.83)、(25.64± 0.41 )、(26.83±1.26)μmol/g ,MCST组分别为(22.37±0.70)、(25.69±0.42 )、(26.78±1.24)μmol/g 。随治疗时间延长LF-NTST组、MCST组结肠穿孔愈合部位HC含量逐渐升高( P 均<0.05)。治疗第7、14、21天LF-NTST组、MCST组爆破压、羟脯氨酸含量间差异无统计学意义( P 均>0.05)。结论 LF-NTST、MCST修复后的结肠穿孔猪穿孔愈合情况均较好。Objective To compare the safety and reliability of laminated film nickel-titanium alloy stent tube(LF-NTST)and modified colon sac tube(MCST)for mediate stage repair of colorectal perforation in Tibet miniature pigs. Methods Colorectal perforationmodels of Tibet miniature pigs were established, and then they were randomly divided into the LF-NTST group and MCST group. On the 7th, 14th, and 21st days after procedure, the healing of the perforation was evaluated by examining thebursting pressure (BP)and hydroxyprolinecontent (HC) at site of the anastomosis. Results On the 7th, 14th and 21st days of treatment, the BP was (27.21±0.98),(35.77±0.72), and (38.13±0.92) Kpa, respectively, in the LF-NTST group, versus (26.83±0.91),(35.23±0.55), and (37.20±0.95) Kpa, respectively, in theMCST group. The BP in the FR-NTST group and MCST group gradually increased over the treatment time (both P < 0.05 ). On the 7th, 14 th and 21st days of treatment, the HC of colonic perforation healing site was (22.40±0.83),(25.64± 0.41 ), and (26.83±1.26)μmol/g, respectively, in the LF-NTST group, versus (22.37±0.70),(25.69±0.42), and (26.78±1.24)μmol/g, respectively, in the MCST group. The HC in the colonic perforation healing site of LF-NTST group and MCST group increased gradually with the treatment time (all P <0.05). There were no significant differences in BP or HC between the LF-NTST group and MCST group on the 7th, 14th and 21st days of treatment (both P >0.05). Conclusion Both LF-NTST and MCST can effectively repair colorectal perforation.

关 键 词：覆膜镍钛合金支架管 改良型结肠液囊管 结直肠穿孔 结肠穿孔 结肠穿孔修复 爆破压 羟脯氨酸 

分 类 号：R608[医药卫生—外科学]