中老年人群生活方式因素与白细胞计数的相关性  

Correlation of Lifestyle Factors with White Blood Cell Count in the Middle-aged and Elderly Populations

作　　者：郭蔷 何诗琪 牟轩汶 何美安 邬堂春[1] 张晓敏[1] Guo Qiang;He Shiqi;Mu Xuanwen(Department of Occupational and Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系

出　　处：《华中科技大学学报（医学版）》2019年第3期298-304,共7页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家重点研发计划资助项目(No.2016YFC0900800)

摘　　要：目的 探讨中老年人群生活方式因素与外周血总白细胞(WBC)及分类WBC计数的相关性。方法研究人群来源于东风-同济(DFTJ)队列第1次随访调查到的38295名东风汽车公司(DMC)离退休职工。排除患有冠心病(CHD)、中风、癌症,严重心电图异常、WBC计数和关键协变量缺失的人群后,最终纳入22765名研究对象。纳入分析的研究对象均完成了问卷调查、体格检查、生化指标检查和血液样本采集。采用广义线性模型分析生活方式因素与WBC计数的相关性。结果多因素广义线性回归分析结果显示,与各参照组相比,体质指数(BMI)≥28 kg/m ^2 (β=0.307, P <0.001)、男性腰臀比(WHR)≥0.95或女性WHR ≥0.90(β=0.298, P <0.001)、现在吸烟量≥20支/d(β=0.690, P <0.001)、夜间睡眠≥9 h(β=0.058, P =0.013)的人群,其总WBC计数显著升高;而现在饮酒量≥60 g/d(β=-0.230, P <0.001)、运动量≥42 MET-h/周(β=-0.085, P =0.001)的人群,其总WBC计数显著降低。随着低风险生活方式因素增多,其与WBC计数之间的负相关强度逐渐增大。结论中老年人群保持正常BMI和较低WHR、不吸烟、适量饮酒、保持适量睡眠和较高运动量等低风险生活方式因素与WBC计数降低呈显著相关。随着低风险生活方式因素的增多,其与WBC计数之间的负相关强度逐渐增大。Objective To analyze the correlations of lifestyle factors with peripheral total and differential white blood cell(WBC)counts in the middle-aged and elderly populations. Methods All participants were from the Dongfeng-Tongji(DFTJ)cohort,including 38295 retired employees from the Dongfeng Motor Corporation(DMC)at the first follow-up survey.After excluding participants with coronary heart disease(CHD),stroke,cancer,or severely abnormal electrocardiogram and those with missing data of WBC count or important covariates,finally a total of 22765 participants were included in this study.All participants completed baseline questionnaires,physical examinations,clinical biochemical tests and blood sample collection.Generalized linear models were used to analyze the correlations of lifestyle factors with total and differential WBC count. Results Compared with the respective reference groups,participants with body mass index(BMI)≥28 kg/m ^2 (β=0.307, P <0.001),waist-to-hip ratio(WHR)≥0.95(men)/≥0.90(women)(β=0.298, P <0.001),current smoking ≥20 cigarettes/day(β=0.690, P <0.001),nighttime sleep duration ≥9 h/day(β=0.058, P =0.013)had significantly higher total WBC count,while participants with alcohol consumption of ≥60 g/day(β=-0.230, P <0.001),physical activity level ≥42 MET-h/week (β=-0.085 , P =0.001)had significantly lower total WBC count.Low-risk lifestyle factors were negatively correlated with total and differential WBC counts,and the negative correlation coefficients increased as low-risk lifestyle factors increased. Conclusion Normal BMI,low WHR,non-current smoking,light alcohol consumption,moderate nighttime sleep duration and high physical activity are significantly correlated with decreased WBC count.Low-risk lifestyle factors are negatively correlated with WBC count,and the negative correlation coefficients increase as low-risk lifestyle factors increased.

关 键 词：白细胞计数 生活方式 横断面研究 

分 类 号：R195[医药卫生—卫生统计学]