微创经皮肾穿刺气压弹道碎石对肾结石患者血清及尿液表皮生长因子水平的影响  

Effect of minimally invasive percutaneous nephrolithotomy pneumatic lithotripsy and urinary epidermal growth factor levels in patients with renal calculi

作　　者：苏枝强 SU Zhi-qiang(the People's Hospital of Xixiang County, Hanzhong 723500, China)

机构地区：[1]西乡县人民医院

出　　处：《临床医学研究与实践》2019年第18期58-60,共3页Clinical Research and Practice

摘　　要：目的探究微创经皮肾穿刺气压弹道碎石对肾结石患者血清及尿液中表皮生长因子水平的影响。方法选取我院2017年7月至2018年6月收治的60例肾结石患者为研究对象,采用数字单双号随机分组法将其分为对照组和观察组,每组30例。对照组采用体外冲击波碎石术治疗,观察组采用微创经皮肾穿刺气压弹道碎石术治疗。比较两组手术时间、术中出血量、住院时间、结石清除率、复发率、并发症发生率及血清、尿液中表皮生长因子(EGF)水平。结果两组患者手术时间、住院时间比较,差异无统计学意义(P>0.05);观察组术中出血量多于对照组(P<0.05)。观察组结石清除率高于对照组,复发率、并发症发生率均低于对照组,差异有统计学意义(P<0.05)。术前,对照组与观察组血清及尿液EGF水平比较,差异无统计学意义(P>0.05);术后第1、3、7天,观察组血清及尿液EGF水平均低于对照组,差异有统计学意义(P<0.05)。结论微创经皮肾穿刺气压弹道碎石治疗肾结石的结石清除率高,复发率及并发症发生率低,可改善血清及尿液EGF水平,值得临床推广应用。Objective To investigate the effect of minimally invasive percutaneous nephrolithotomy pneumatic lithotripsy on the levels of epidermal growth factor in serum and urine of patients with renal calculi. Methods A total of 60 patients with renal calculi admitted in our hospital from July 2017 to June 2018 were selected as the research objects and divided into control group and observation group according to the method of random grouping of single and double numbers, with 30 cases in each group. The control group was treated with extracorporeal shock wave lithotripsy, while the observation group was treated with minimally invasive percutaneous nephrolithotomy pneumatic lithotripsy. The operation time, intraoperative bleeding volume, hospital stay, stone clearance rate, recurrence rate, incidence of complications and the levels of epidermal growth factor (EGF) in serum and urine were compared between the two groups. Results There were no significant differences in operation time and hospital stay between the two groups (P>0.05). The intraoperative bleeding volume in the observation group was more than that in the control group (P<0.05). The stone clearance rate in the observation group was higher than that in the control group, and the recurrence rate and incidence of complications were lower than those in the control group (P<0.05). There were no significant differences in the levesl of EGF in serum and urine between the control group and the observation group before operation (P>0.05). The levels of EGF in serum and urine of the observation group were lower than those of the control group on the 1st, 3rd and 7th day after operation, and the differences were statistically significant (P<0.05). Conclusion Minimally invasive percutaneous nephrolithotomy pneumatic lithotripsy has high stone clearance rate, low recurrence rate and incidence of complication. It can improve the levels of EGF in serum and urine, and is worthy of clinical promotion and application.

关 键 词：微创经皮肾穿刺气压弹道碎石 肾结石 表皮生长因子 

分 类 号：R699.2[医药卫生—泌尿科学]