妊娠晚期凝血功能四项、D-二聚体、FDP指标检测的临床意义  

Clinical significance of detection for four coagulation functions, D-dimer and FDP in the third trimester of pregnancy

作　　者：卢榕[1,2] 刘洪爱 江新泉[2] LU Rong;LIU Hong-ai;JIANG Xin-quan(Dept.of Clinical Laboratory,the First Affiliated Hospital of the University of Xiamen,Xiamen 361000,China;College of Public Health,Shandong First Medical University & Shandong Academy of Medical Sciences,Taian 271016,China;Taishan Sanatorium of Shandong Province,Taian 271000,China)

机构地区：[1]厦门大学附属第一医院检验科,福建厦门361000 [2]山东第一医科大学(山东省医学科学院)公共卫生学院,山东泰安271016 [3]山东省泰山疗养院检验科,山东泰安271000

出　　处：《泰山医学院学报》2019年第7期518-520,共3页Journal of Taishan Medical College

摘　　要：目的检测妊娠晚期凝血功能四项[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)]以及D-二聚体(D-D)、纤维蛋白(原)降解产物(FDP)水平,分析其临床意义,为临床工作提供理论依据。方法选取2017年1月—12月于厦门大学附属第一医院就诊的320例妊娠晚期妇女为妊娠晚期组,选取同期的50例健康非妊娠妇女为健康对照组。比较两组妇女的APTT、PT、TT、FIB以及FDP和D-D的水平。结果妊娠晚期组妇女凝血四项中的PT、TT、APTT均短于健康对照组,而FIB则高于健康对照组(均P<0.05);妊娠晚期组妇女FDP、D-D水平明显高于健康对照组,差异均具有统计学意义(均P<0.05)。结论在妊娠晚期,临产孕妇机体处于高凝状态,动态监测凝血功能指标对预防产中及产后异常出血具有重要临床意义。Objective:To detect the levels of four coagulation functions,D-dimer and FDP in the third trimester of pregnancy,and analyze the clinical significance to provide theoretical basis for clinical work.Methods:A total of 320 pregnant women in the third trimester of pregnancy from January to December 2017 were selected as the third trimester group.Fifty healthy non-pregnant women in the same period were selected as the healthy controls.The activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),fibrin(original)degradation products(FDP)and D-dimer(D-D)levels were compared.Results:The values of PT,TT and APTT in the four groups of coagulation in the third trimester group were lower than those in the healthy control group,and the values of FIB,FDP and DD in the late pregnancy group were significantly higher than those in the healthy control group.The difference was statistically significant(P<0.05).Conclusion:In the third trimester of pregnancy,the pregnant woman's body is in a hypercoagulable state.Dynamic monitoring of coagulation function has important clinical significance for preventing abnormal bleeding during and after delivery.

关 键 词：妊娠晚期 D-二聚体 FDP 凝血功能四项 

分 类 号：R446.1[医药卫生—诊断学]