动脉粥样硬化指数与血清抗心磷脂抗体及抗β2糖蛋白1抗体水平的相关性研究  

Study on the correlation between atherogenic index and serum anti-cardiolipin antibody and anti-β2 glycoprotein 1 antibody levels

作　　者：王君君[1] 章帆[1] 姜丰[1] 陈坚[1] 胡丽娟[1] 郑晓勇 王瑜敏[1] WANG Junjun;ZHANG Fan;JIANG Feng;CHEN Jian;HU Lijuan;ZHENG Xiaoyong;WANG Yumin(Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第一医院医学检验中心

出　　处：《中国动脉硬化杂志》2019年第7期611-614,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨动脉粥样硬化指数(AI)与血清抗心磷脂抗体(ACA)及抗β2糖蛋白1抗体(aβ2GP1)水平的关系,为动脉粥样硬化(As)的预防控制提供参考依据。方法选择温州医科大学附属第一医院2017年3月至2018年6月住院患者34 598例,检测其血清ACA、ACA-IgA、ACA-IgG、ACA-IgM、aβ2GP1、aβ2GP1-IgA、aβ2GP1-IgG、aβ2GP1-IgM、总胆固醇、高密度脂蛋白胆固醇、同型半胱氨酸(Hcy)、载脂蛋白A1(ApoA1)。计算AI,根据AI将患者分为高危组(AI≥4)和低危组(AI<4)。利用统计软件进行相关分析。结果高危组ACA和aβ2GP1的阳性率均高于低危组(χ^2=23.276和17.603,均P=0.000),且年龄、ACA-IgA、ACA-IgG、aβ2GP1-IgA、aβ2GP1-IgG、Hcy水平亦均高于低危组(均P<0.05),而ApoA1水平低于低危组(P=0.000)。相关性分析显示,AI与ACA-IgA、ACA-IgG、aβ2GP1-IgA、aβ2GP1-IgG、Hcy均呈正相关(r=0.048、0.032、0.094、0.014、0.142,均P<0.01),与ApoA1呈负相关(r=-0.447,P=0.000)。多因素Logistic回归分析显示,年龄、ACA-IgA、Hcy、aβ2GP1是As的危险因素,ApoA1是As的保护因素。结论随着ACA-IgA、aβ2GP1、Hcy、年龄的升高,ApoA1的降低,患者AI逐渐升高,As危险度也相应升高。临床上应密切关注ACA、aβ2GP1、Hcy、ApoA1异常的高龄患者,以预防As的发生。Aim To explore the relationship between atherogenic index(AI) and serum anti-cardiolipin antibody(ACA) and anti-β2 glycoprotein 1 antibody(aβ2 GP1), and to provide reference for the prevention and control of atherosclerosis(As). Methods 34 598 hospital patients were selected from the First Affiliated Hospital of Wenzhou Medical University from March 2017 to June 2018. Serum ACA, ACA-IgA, ACA-IgG, ACA-IgM, aβ2 GP1, aβ2 GP1-IgA, aβ2 GP1-IgG, aβ2 GP1-IgM, total cholesterol, high density lipoprotein cholesterol, homocysteine(Hcy) and apolipoprotein A1(ApoA1) were detected. AI was calculated and the patients were divided into high-risk group(AI≥4) and low-risk group(AI<4) according to AI. Correlation analysis was performed by statistical software. Results The positive rates of ACA and aβ2 GP1 in high-risk group were higher than those in low-risk group(χ^2=23.276 and 17.603, all P=0.000), and the levels of age, ACA-IgA, ACA-IgG, aβ2 GP1-IgA, aβ2 GP1-IgG and Hcy in high-risk group were also higher than those in low-risk group(all P<0.05), while the level of ApoA1 was lower than that in low-risk group(P=0.000). The correlation analysis showed that AI was positively correlated with ACA-IgA, ACA-IgG, aβ2 GP1-IgA, aβ2 GP1-IgG and Hcy(r=0.048, 0.032, 0.094, 0.014, 0.142, all P<0.01), and negatively correlated with ApoA1(r=-0.447, P=0.000). Multivariate Logistic regression analysis showed that age, ACA-IgA, Hcy and aβ2 GP1 were risk factors for As, and ApoA1 was protective factor for As. Conclusion With the increase of ACA-IgA, aβ2 GP1, Hcy and age, the decrease of ApoA1, AI gradually increases, and As risk increases accordingly. Clinically, we should pay close attention to the elderly patients with abnormal ACA, aβ2 GP1, Hcy and ApoA1 in order to prevent the occurrence of As.

关 键 词：动脉粥样硬化 动脉粥样硬化指数 抗心磷脂抗体 抗Β2糖蛋白1抗体 同型半胱氨酸 载脂蛋白A1 

分 类 号：R54[医药卫生—心血管疾病]