危重血栓性疾病诊断中凝血标志物与炎性因子的研究  

Study on Coagulation Markers and Inflammatory Factors in the Diagnosis of Critical Thrombotic Diseases

作　　者：班素芬 李广华[2] BAN Su-fen;Li Guang-hua(Department of Laboratory, Integrated Chinese and Western Medicine Hospital, Southem Medical University Guangzhou,5103152,Chuna;Inspection Department of Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences), Guangzhou,510080, China)

机构地区：[1]南方医科大学中西医结合医院检验科,广州510315 [2]广东省人民医院检验科(广东省医学科学院),广州510080

出　　处：《血栓与止血学》2019年第3期363-366,共4页Chinese Journal of Thrombosis and Hemostasis

基　　金：广东省医学科学技术研究基金项目A2015442

摘　　要：目的分析危重血栓性疾病诊断中凝血标志物与炎性因子的应用价值。方法 2013年9月~2018年2月,于我院诊治的危重疾病患者中选取238例为研究对象,将其是否有凝血功能障碍出现作为依据,分为甲(出现血栓性疾病)、乙(未出现血栓,但基础疾病相同)两组,对其炎性因子和凝血标志物进行检测,对这两者之间的相关性及其在危重血栓性疾病诊断中的应用价值进行探究。结果甲组患者CRP(C反应蛋白)、IL-6(白介素-6)、PCT(降钙素原)等炎症因子水平均高于乙组,组间差异存在统计学意义,t=50.3360、42.6325、57.5695,P<0.05;甲组患者D-D(D二聚体)、FDP(纤维蛋白原溶解产物)、PIC(溶酶-a2纤溶酶抑制剂)、TAT(凝血酶一抗凝血酶Ⅲ复合物)、TM(血栓调节蛋白)均高于乙组,组间差异存在统计学意义,t=20.1296、20.1296、9.6338、15.6398、18.8857,P<0.05;甲、乙两组t-PAIC水平对比,组间差异不存在统计学意义,t=0.1525,P>0.05;相关性分析结果显示,血浆凝血标志物中的TM和炎症因子之间存在相关性,和IL-6、CRP以及PCT之间的相关系数分别为0.028、0.251、0.291。结论危重血栓性疾病患者存在纤溶与凝血系统活化现象,机体炎症水平明显升高,炎性因子和凝血因子之间相互作用,共同发挥促炎与促凝作用。Objective To analyze the application value of coagulation markers and inflammatory factors in the diagnosis of critical thrombotic diseases.Methods From September 2013 to February 2018,238 patients with critical illness diagnosed and treated in our hospital were selected as subjects.Whether they had coagulopathy or not,they were divided into A(the occurrence of thrombotic diseases)and B(There were no thrombosis,but the underlying disease was the same.The inflammatory factors and coagulation markers were tested in both groups,and the correlation between them and their application value in the diagnosis of critical thrombotic diseases were explored.Results The levels of CRP(C-reactive protein),IL-6(interleukin-6)and PCT(procalcitonin)in group A were higher than those in group B.There was significant difference between groups(t=50.3360,42.6325).,57.5695,P<0.05;group A patients DD(D-dimer),FDP(fibrinogen lysate),PIC(lysozyme-a2 plasmin inhibitor),TAT(thrombin-anti-thrombin)III complex),TM(thrombomodulin)were higher than group B,the difference between the groups was statistically significant,t=20.1296,20.1296,9.6338,15.6998,18.8857,P<0.05;group A and group b t-PAIC level In contrast,there was no statistically significant difference between the groups,t=0.1525,P>0.05.Correlation analysis showed that there was a correlation between TM and inflammatory factors in plasma coagulation markers,and IL-6,CRP and PCT.The correlation coefficients between them are 0.028,0.251,and 0.291,respectively.Conclusion Patients with critical thrombotic diseases have fibrinolysis and coagulation system activation,the body’s inflammation level is significantly increased,and the interaction between inflammatory factors and coagulation factors plays a role in promoting inflammation and procoagulant.

关 键 词：危重血栓性疾病 炎性因子 凝血标志物 应用价值 

分 类 号：R446[医药卫生—诊断学]