慢性阻塞性肺疾病急性发作期合并呼吸衰竭患者血栓前状态及凝血功能的变化  

Changes of Pre-thrombosis State and Coagulation Function in Patients with Acute Onset of Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure

作　　者：王学凤 龙明伟 阿依石布 WangXue-feng;Long Ming-wei;Aishibu(Department of Respiratory Medicine, Liangshan Second People's Hospital, Liangshan ,615000, China)

机构地区：[1]凉山州第二人民医院呼吸内科

出　　处：《血栓与止血学》2019年第3期423-425,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)急性发作期合并呼吸衰竭患者血栓前状态及凝血功能的变化研究。方法收集2013年5月-2015年10月我院收治的42例COPD急性发作期合并呼吸衰竭患者(研究组)及同期于我院治疗的42例无合并症的COPD患者(对照组)为研究对象,观察2组血栓前状态[D-二聚体(D-D)、血管性血友病因子(vWF)]、动脉血氧指标[血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血氧pH值(pH)]、凝血功能指标[活化部分凝血活酶时间(aPTT)、纤维蛋白原(Fbg)、血浆凝血酶时间(TT)]、急性发作期合并呼吸衰竭与血栓前状态、凝血功能等进行相关性分析。结果研究组D-D、vWF、PaCO2、、Fbg较对照组明显高,PaO2、aPTT、TT明显下调(P<0.05);Spearman相关性分析显示,COPD急性发作期合并呼吸衰竭与D-D、vWF、aPTT、TT、Fbg、PaCO2呈正相关(r1=0.435、r2=0.421、r3=0.512、r4=0.536、r5=0.508、r6=0.528),与PaO2呈负相关(r7=-0.638)。结论 COPD急性发作期合并呼吸衰竭患者存在血栓前状态、凝血功能、动脉血氧异常表达状态,临床应对此类患者给予高度重视。Objective To investigate chronic obstructive pulmonary disease(COPD)Study on the changes of pre-thrombosis state and coagulation function in patients with acute onset complicated with respiratory failure.Methods 42 patients with acute onset of COPD complicated with respiratory failure(the study group)and 42 COPD patients(control group)treated in our hospital during the same period were collected from May 2013 to October 2015.2 groups of pre-thrombosis states were observed[D-dimer(D-D),Vascular hemophilia Factor(vWF)],arterial oxygen index[blood oxygen partial pressure(PaO2),arterial blood carbon dioxide partial pressure(PaCO2),Blood oxygen pH(pH)],coagulation function index[activation partial coagulation enzyme time(aPTT),Fibrinogen(Fbg),plasma thrombin time(TT)],Correlation analysis of respiratory failure with pre-thrombosis state and coagulation function during acute onset.Results The Study group D-D,vWF,PaCO2,Fbg were significantly higher than the control group,PaO2,aPTT and TT were significantly reduced(P<0.05).Spearman correlation analysis showed that the acute onset of COPD combined with respiratory failure was positively correlated with D-D,vWF,aPTT,TT,Fbg and PaCO2(r1=0.435,r2=0.421,r3=0.512,r4=0.536,r5=0.508,r6=0.528),negatively correlated with PaO2(r7=-0.638).Conclusion Pre-thrombosis state,coagulation function and abnormal expression of arterial oxygen in patients with acute onset of COPD complicated with respiratory failure,which should be paid great attention to in clinic.

关 键 词：慢性阻塞性肺疾病 急性发作期 呼吸衰竭 血栓前状态 

分 类 号：R563[医药卫生—呼吸系统]